阿托伐他汀联合降压治疗对老年高血压患者平滑指数的影响

目的 观察应用阿托伐他汀调脂联合贝那普利和氨氯地平对老年高血压患者平滑指数的影响.方法 选取2013年10月至2014年2月上海市嘉定区南翔医院≥2级老年高血压患者120例,随机分为单纯降压组及调脂联合降压组,各60例.单纯降压组患者接受贝那普利和氨氯地平治疗,调脂联合降压组在此基础上加用阿托伐他汀（10mgqn po）调脂治疗.治疗3个月和6个月后随访,两组分别进行血脂及24 h动态血压监测,记录24 h平均收缩压（24 h SBP）和平均舒张压（24 h DBP）,计算24h收缩、舒张压平滑指数（SISBP和SIDBP）及脉压（PP）、脉压指数（PPI）,分别比较两组患者治疗前后血脂、动态血压值及稳定性的变化.结果 治疗3个月及个6月后,两组患者血压均控制良好.与单纯降压组相比,调脂联合降压组患者的总胆固醇及甘油三酯水平明显降低,PP及PPI明显降低（P＜0.05）,而SISBP和SIDBP明显升高（P＜0.05,P＜0.01）.结论 阿托伐他汀调脂联合降压治疗能更加有效降低≥2级高血压患者动态血压的PP及PPI,并且明显提高血压平滑指数,能有效减轻老年高血压患者靶器官损害.

The effect of Atorvastatin combination antihypertensive on smoothness index in elderly patients with essential hypertensionThe effect of Atorvastatin combination antihypertensive on smoothness index in elderly patients with essential hypertension

Objective To investigate the effect of Atorvastatin combined with Benner Pury, Amlodipine on smoothness index in elderly patients with essential hypertension. Methods 120 cases of elderly patients with hypertension were selected. According to the random number table method, they were divided into the simple blood control group and the combination antihypertensive of lipid regulation group with 60 cases in each. The simple blood control group was treated with Amlodipine and Benner Pury oral control of blood pressure, blood pressure control target value for 140/90 mm Hg. The combination antihypertensive of lipid regulation group was treated based on the therapy with oral Atorvastatin added. After 3 or 6 month of treatment, serum lipid and 24 h ambula- tory blood pressure monitoring of both groups were completed. Record the 24 h systolic blood pressure （24 h SBP） and 24 h mean diastolic blood pressure（24 h DBP）, systolic, diastolic pressure calculation of 24 h smoothness in- dex （SISBP and SIDBP） and pulse pressure （PP）, pulse pressure index （PPI）. Changes of blood lipid, blood pressure value of dynamic stability, between the two groups of patients before and after treatment were compared. Results After 3 or 6 month treatment, 2 groups of patients were well controlled blood pressure. Compared with the simple hypertension group, there was significantly decreased total cholesterol and triglyceride levels, PP and PPI in the combination antihypertensive of lipid regulation group, while SISBP and SIDBP increased significantly （P〈0.05, P〈 0.01 ）. Conclusion The application of Atorvastatin lipid regulation with antihypertensive combination can effectively decrease ≥ 2 level dynamic blood pressure PP and PPI in patients with hypertension, and obviously improve the smoothness index, can effectively reduce the target organ damage in patients with hypertension in the elderly.