肾康注射液联合益气芡实合剂治疗气虚血瘀型慢性肾小球肾炎疗效观察

目的:观察肾康注射液联合益气芡实合剂治疗气虚血瘀型慢性肾小球肾炎的临床疗效。方法:将60例气虚血瘀型慢性肾小球肾炎患者,按照随机数字表法分为2组各30例。对照组在常规治疗基础上加用肾康注射液治疗,观察组在对照组基础上给予益气芡实合剂治疗,2组疗程均为3月,并对患者随访半年,观察2组的临床疗效以及肾功能相关指标的变化。结果:总有效率观察组为93.3%,对照组为70.0%,观察组的总有效率高于对照组(P0.05)。治疗后2组24 h尿蛋白定量、血肌酐、尿素氮相对治疗前均下降(P0.05),观察组24 h尿蛋白定量、血肌酐、尿素氮变化情况均优于对照组(P0.05)。结论:肾康注射液联合益气芡实合剂治疗气虚血瘀型慢性肾小球肾炎,可改善患者肾功能,延缓患者病情恶化。

Effect of Shenkang Injection and Yiqi Qianshi Mixture for Chronic Glomerulonephritis with Qi Deficiency and Blood Stasis

Objective： To explore the clinical efficacy of Shenkang injection and Yiqi Qianshi mixture for the treatment of chronic glomerulonephritis. Methods： Sixty patients of chronic glomerulonephritis with qi deficiency and blood stasis were divided into control group and observation group, 30 cases in each group. Both groups received conventional treatment and Shenkang injection intravenously, and the observation group was given Yiqi Qianshi mixture additionally. The treatment lasted for three months, and the follow up covered six months. Clinical effect and related indexes of renal function were observed. Results： The total effective rate was 93.3% in the observation group, and was 70.0% in the control group, the difference being significant （P 〈 0.05）. After treatment, 24-hour urinary protein, serum creatinine（SCr）, blood urea nitrogen（BUN） were deceased significantly in both groups（P 〈 0.05 compared with those before treat- ment）. The improvement of 24-hour urine protein, SCr, BUN in the observation group was superior to that in the control group（P 〈 0.05）. Conclusion： Shenkang injection and Yiqi Qianshi mixture can improve renal function of patients with chronic glomerulonephritis, and delay the progression of chronic glomeru-Ionephritis.