| 大鼠肝肠联合移植对移植肠内ATP酶、AKP和AChE活性的影响 |
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| 引用本文： | 殷光甫,胡道松,林传友,曹福元,茹立强,孙晓毅,魏明发,王果.大鼠肝肠联合移植对移植肠内ATP酶、AKP和AChE活性的影响[J].华中科技大学学报(医学版),2001,30(3):200-202. |
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| 作者姓名： | 殷光甫 胡道松 林传友 曹福元 茹立强 孙晓毅 魏明发 王果 |
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| 作者单位： | 1. 华中科技大学同济医学院基础医学院神经生物学教研室,
2. 华中科技大学同济医学院附属同济医院小儿外科, |
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| 基金项目： | 国家自然科学基金资助课题（No.393700597）卫生部科学基金课题（No.0733-501） |
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| 摘 要： | 采用肝/小肠联合移植模型，观察对移植肠ATPase、AKP和AChE活性的影响，结果发现肝小肠联合移植与单纯小肠移植相比①前者能延长受体动物的存活期，并对移植小肠产生的免疫排斥反应有明显的减轻和延迟作用；②肝小肠联合移植的移植物内ATPase、AKP和AChE活性反应较好。结果表明上述3种酶活性的改变能相应地反映移植器官产生免疫排斥反应的程度和受体动物的生存状态,并可以作为器官移植后临床监测中的一种辅助措施。
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| 关 键 词： | 肝肠联合移植 ATPase AKP AChE |
| 修稿时间： | 2000年9月28日 |
The Changes of
Triphosphatase |
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| Yin Guangfu,Hu Daosong,Lin Chuanyou et al.The Changes of
Triphosphatase[J].Journal of Huazhong University of Science and Technology(Health Sciences),2001,30(3):200-202. |
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| Authors: | Yin Guangfu Hu Daosong Lin Chuanyou |
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| Institution: | Yin Guangfu,Hu Daosong,Lin Chuanyou et al Department of Neurobiology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | To observe the changes of triphosphatase (ATPase), alkalinophosphatase (AKP) and acytelcholinesterase (AchE) activities in the intestinal allografts after combined liver intestine transplantation, the combined liver intestine transplantation model was used. The results showed that: (1) After combined liver intestine transplantation, the recipient survival prolonged and the immune rejection was significantly decreased or delayed as compared with that produced by the intestinal allotransplantation alone; (2) ATPase, AKP and AChE activities in the combined transplanted intestine allografts were much stronger than those in the alone transplanted ones. The results suggested that the changes of the three kinds of the enzyme activities might reflect the degree of immune rejection and the condition of recipient survival, and could be helpful for monitoring the rejection clinically after organ transplantation. |
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| Keywords: | combined liver/intestine transplantation triphosphatase alkalinophosphatase acytelcholinesterase |
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