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| MMP-2和TIMP-2mRNA在大鼠颈动脉粥样硬化中的动态表达 | |
| 引用本文： | 王庆林,郭向东,邵坤,贾娟,万光瑞.MMP-2和TIMP-2mRNA在大鼠颈动脉粥样硬化中的动态表达[J].河南职工医学院学报,2011,23(6):651-653. |
| 作者姓名： | 王庆林 郭向东 邵坤 贾娟 万光瑞 |
| 作者单位： | 1. 河南职工医学院儿科教研室,郑州,451191 2. 河南中医学院第一附属医院耳鼻喉科,郑州,450000 3. 新乡医学院生理教研室,河南新乡,453003 |
| 基金项目： | 河南省教育厅自然科学研究计划项目(2009A180015); 河南省新乡市科技局课题(08S064) |
| 摘 要： | 目的 探讨基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶组织抑制剂-2(TIMP -2)在颈动脉粥样硬化(AS)发生、发展中的作用.方法 将40只SD大鼠随机分正常对照组和钳-脂组(给予血管钳夹术和高脂饮食),钳-脂组又分为2、6、10周三个亚组,应用RT-PCR的方法,观察MMP-2、TIMP-2和MMP-2/... |
| 关 键 词： | 动脉粥样硬化 钳夹 基质金属蛋白酶-2 基质金属蛋白酶组织抑制剂-2 |
Dynamic Expression of MMP-2 and TIMP-2 in Rat Carotid Artery Atherosclerosis by Clamping and High Fat Feeding |
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| WANG Qing-lin,GUO Xiang-dong,SHAO Kun,et al.Dynamic Expression of MMP-2 and TIMP-2 in Rat Carotid Artery Atherosclerosis by Clamping and High Fat Feeding[J].Journal of Henan Medical College For Staff and Workers,2011,23(6):651-653. | |
| Authors: | WANG Qing-lin GUO Xiang-dong SHAO Kun |
| Institution: | WANG Qing-lin,GUO Xiang-dong,SHAO Kun,et al |
| Abstract: | Objective To explore the effect of matrix metalloproteinase-2(MMP-2) and tissue inhibitor of metalloproteinase-2(TIMP-2) in the occurrence and development of artery atherosclerosis(AS).Methods Forty SD rats were divided into two groups randomly,the normal control group and the model group(high fat feeding and vascular clamping).The model group was divided into three subgroups of 2 nd,6 th and 10th week.The dynamic variation of MMP-2,TIMP-2 and MMP-2/TIMP-2 mRNA were examined with the method of RT-PCR.Result... |
| Keywords: | artery atherosclerosis clamping matrix metalloproteinase-2 tissue inhibitor of metalloproteinase-2 |
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