原发腹膜癌的临床特点分析

目的探讨原发腹膜癌的临床特点。方法对17例原发腹膜癌的临床资料进行回顾性分析。结果浆液性乳头状腺癌15例,黏液性乳头状腺癌2例。临床表现以腹胀、腹痛、腹水、食欲差、消瘦为主,所有患者术前均误诊为消化系统疾病或卵巢癌,且CA125均高于正常,治疗以肿瘤细胞减灭术为主,术中均腹腔放入顺铂100mg,术后给予以铂类为主的化疗。结论原发腹膜癌是一种起病隐匿,发病率较低的恶性肿瘤,易被误诊,临床应警惕腹胀、腹水患者原发腹膜癌的可能,积极的减瘤术和以PPD为主的腹腔化疗是目前治疗原发腹膜癌的最好方法。CA125可作为诊断及检测预后的有效指标之一。

Analysis on clinical features of primary peritoneum carcinoma

Objective To explore the clinical features of primary peritoneum carcinoma.Methods 17 cases of primary peritoneum carcinoma were retrospectively analyzed from 1993 to 2006.Results There were fifteen cases of primary peritoneal serous papillary carcinoma and two cases of mucinous carcinoma.The ages of the 17 patients were between 41-70 years old,the most common symptoms included abdominal distention and pain, ascites,loss of weigh and anorexia.17 cases misdiagnosed as digestive disease or ovarian cancer before operation.CA125 was higher than that in normal in all patients,17 cases underwent cytoreductice operation,given PPD 100mg in the abdominal cavity and followed by systemic chemotherapy of Cisplatin based regimen. Conclusion Cytoreductives surgery followed by chemotherapy of abdominal cavity with Cisplatin can improve survival rate of patients with primary peritoneum carcinoma.CA125 could be one of effective surveillant markers of this disease.