脓毒血症患者免疫调理治疗研究

目的探讨胸腺肽α1联合血必净对脓毒血症患者免疫功能的影响。方法72例脓毒症患者随即分成治疗组和对照组,对照组参照拯救脓毒症运动中所建议经典治疗方法,治疗组经典治疗基础上加胸腺肽α1联合血必净进行免疫调理治疗,比较两组患者治疗前后APACHEⅡ评分,血浆IL-6水平,T淋巴细胞亚群构成变化,及外周血CD14+单核细胞人类白细胞抗原(HLA-DR)水平变化。结果治疗组患者经免疫调理治疗后APACHEⅡ评分显著降低,其CD14+单核细胞HLA-DR和T细胞亚群CD4+、Th/Ts显著提高,IL-6表达水平明显下降,与对照组比较差异具有显著性(P<0.05)。结论胸腺肽α1联合血必净治疗脓毒症患者,有助于增强机体的免疫防御作用,并抑制过度炎症反应。

Immunomodulation In patients with sepsis treatment

Objective To evaluate the efficacy on immune function by the therapy which combined of thymosin α1 and Xuebijing injection to sepsis.Methods 72 patients with sepsis were randomly divided into two groups.The patients in control group were treated with classical SSC therapy,those intreatment group were treated with the combined thymosin α1 and Xuebijing injection therapy supplemented.The score of APACHEⅡ,the contents of IL-6,the level of HLA-DR,the percentage of CD4+、CD8+、 the rate of CD4+/ CD8+were detected ...