可溶性环氧化物水解酶基因多态性与冠心病的相关性 |
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引用本文: | 黄一伟,;张怀勤,;林斌,;王军,;毛义建.可溶性环氧化物水解酶基因多态性与冠心病的相关性[J].温州医学院学报,2014(8):578-580. |
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作者姓名: | 黄一伟 ;张怀勤 ;林斌 ;王军 ;毛义建 |
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作者单位: | [1]温州医科大学定理临床学院、温州市中心医院心血管内科,浙江温州325000; [2]温州医科大学附属第一医院心血管内科,浙江温州325015; [3]温州医科大学定理临床学院、温州市中心医院中心实验室,浙江温州325000 |
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摘 要: | 目的:研究中国浙江籍汉族人群中可溶性环氧化物水解酶(EPHX2)基因rs2271001位点单核苷酸多态性(single nucleotide polymorphism,SNP)与冠心病的相关性.方法:176例冠心病患者(至少1支冠状动脉血管内径狭窄≥50%)为冠心病组,选取同期179例冠脉造影正常者作为对照组.采用PCR和基因测序方法,检测rs2271001位点的SNP.结果:在rs2271001位点上检测到3种基因型,其基因型分布符合Hardy-Weinberg平衡定律.冠心病组EPHX2基因rs2271001位点的AG、GG、AA基因型及G、A等位基因分布频率均高于对照组(均P<0.05).结论:EPHX2基因rs2271001位点A/G多态性与冠心病发病存在相关性,G等位基因可能是中国浙江籍汉族人群冠心病患者患病的危险等位基因.
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关 键 词: | 冠心病 多态性 单核苷酸 可溶性环氧化物水解酶 相关性 |
Correlation between EPHX2 gene polymorphisms and coronary heart disease in Chinese population |
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Institution: | HUANG Yiwei,ZHANG Huaiqin,LIN Bin,WANG Jun,MAO Yijian( 1.Department of Cardiology, Dingli Clinical Institute of Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou, 325000; 2.Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015; 3.Department of Central Laboratory, Dingli Clinical Institute of Wenzhou Medical University, Wenzhou Central Hospital, Wenzhou,325000;) |
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Abstract: | Objective:To study the correlation between EPHX2 gene polymorphisms and CHD in Chinese population.Methods:One hundred and seventy-six patients were underwent selected coronary angiography and patients having more than one major coronary vessel with at least 50% stenosis were defined as CHD.The control group consisted of 179 healthy subjects.rs2271001 polymorphisms were detected by polymerase chain reaction (PCR) and gene sequence.Results:Three kinds of genotypes at the rs2271001 were detected,and no deviation was observed from Hardy-Weinberg equilibrium.The frequency of allele G,A and genotype AG,GG and AA were increased in CHD group when compared with control group (P<0.05).Conclusion:These results suggest that rs2271001 A/G polymorphism be associated with CHD in Chinese population,the G allele may be a risk allele of CHD in Chinese Han nationality in Zhejiang province. |
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Keywords: | coronary heart disease polymorphism single-nucleotide EPHX2 relevance |
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