中枢神经系统铁沉积与血管性认知障碍研究进展

血管性认知障碍(VCI)是仅次于阿尔茨海默病的第二大常见认知障碍性疾病,目前尚无有效的干预手段.铁是人体必需的一种金属元素,不仅参与ATP和DNA合成,还与髓鞘合成、神经递质循环密切相关,当铁稳态被破坏时出现中枢神经系统铁沉积.研究表明中枢神经系统铁沉积与认知障碍性疾病有关,如阿尔茨海默病和VCI,但目前对这种联系的具...

Iron deposition in central nervous system and vascular cognitive impairment:research progress

Vascular cognitive disorder (VCI) is the second most common cognitive disorder after Alzheimer"s disease (AD), and there is no effective intervention method at present. Iron is an essential metal element for the human body. It is not only involved in the synthesis of ATP and DNA, but also closely related to myelin synthesis and neurotransmitter circulation. When iron homeostasis is disrupted, iron deposition occurs in the central nervous system. Several studies have shown that iron deposition in the central nervous system is associated with cognitive disorders, such as AD and VCI, but the specific mechanism of this association is still poorly understood. This paper summarized the formation and classification of iron deposition in central nervous system, overviewd the correlation between iron deposition in central nervous system and different types of VCI, preliminarily discussed the possible mechanism of iron deposition in central nervous system to induce VCI, and tried to find the basic and clinical relationship between iron deposition in central nervous system and VCI.