肾移植后不同免疫抑制剂的应用研究

目的：分析肾移植后不同的免疫抑制用药方案对移植效果、副作用及长期存活的影响。方法：根据不同用药组合将201例患者分为环孢素A(QA)、硫唑嘌呤(Aza)、强的松(Pred)三联治疗组，QA、霉酚酸酯(MMF)、Pred三联治疗组，CsA和Pred二联治疗组，Aza和Pred传统二联治疗组，统计分析4组患者排斥反应和肾存活情况。结果：三联治疗组1、3、5年存活率高于传统二联治疗组，排斥反应发生率也明显降低。结论：肾移植后三联治疗组早期急性排斥反应发生率明显低于二联治疗组。

The Effects of Different Immunosuppressants on Renal Transplantation

Objective: To analyze the influence of different combinations of immunosuppressants on therapeutic effects, side effects and long term survival. Methods: According to different combinations of immunosuppressants, 201 cases are divided into four groups: (1) cyclosporine (CsA), azathioprine(Aza) and prednisolone; (2) cyclosporine, mycophenolate mofetil (MMF) and prednisolone (Pred); (3) cyclosporine, and prednisolone; (4) cyclosporine and azathioprine. The rejection frequency and the survival of kidneys were investigated, and statistical analysis was made. Results: Those treated with three drugs had a much higher survival rate and a much lower rejection rate than those with two drugs in 1 year, 3 years and 5 years periods. Conclusion: Renal transplant recipients treated with CsA, Aza and Pred have a much lower acute rejection frequency than those treated with Aza and Pred in the early period.