| 褐藻氨酸对M-胆碱受体的作用 |
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| 引用本文： | 臧东莲,邵伯芹,周绪祥,孙世锡.褐藻氨酸对M-胆碱受体的作用[J].青岛大学医学院学报,1993(3). |
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| 作者姓名： | 臧东莲 邵伯芹 周绪祥 孙世锡 |
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| 作者单位： | 青岛医学院药理学教研室
(臧东莲，邵伯芹，周绪祥)，青岛医学院药理学教研室(孙世锡) |
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| 摘 要： | 本文以离体豚鼠回肠作标本,乙酰胆碱作对照剂,阿托品作对抗剂,观察了褐藻氨酸对肠管平滑肌的作用。结果表明,褐藻氨酸使汤平滑肌产生了剂量依赖性的兴奋作用,该作用可被阿托品竞争性对抗。褐藻氨酸的PD_2为3.86,阿托品的PA_2为9.6.提示褐藻氨酸对M-胆碱受体有激动作用。
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| 关 键 词： | 褐藻氨酸 受体 胆碱能 乙酰胆碱 阿托品 回肠 豚鼠 |
EFFECTS OF LAMININE ON GUINEA PIG ILEUM IN VITRO |
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| Zang Donglian,Shao Boqin,Zhou Xuxiang,et al.EFFECTS OF LAMININE ON GUINEA PIG ILEUM IN VITRO[J].Acta Academiae Medicinae Qingdao Universitatis,1993(3). |
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| Authors: | Zang Donglian Shao Boqin Zhou Xuxiang |
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| Institution: | Zang Donglian,Shao Boqin,Zhou Xuxiang,et al Department of Pharmacology |
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| Abstract: | The effects of Laminine on the guinea pig ileum were studied in vitro. The results
showed that Laminine produced a dose-dependent excitative action on the guinea pig
ileum. Atropine caused a parallel shift of the dose-response curve of Laminine to the
right but did not inhibit its maximal response. The PD_2 of Laminie was 3.86 and the
PA_2 of Atropine was 9.6. These results suggest that Laminine has an antogonistic effect
on the M-receptor. |
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| Keywords: | laminine acetylcholine atropine guinea pig ileum receptor cholinergic |
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