| 丹参雌激素样作用及机制研究近况 |
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| 引用本文： | 郭傲玮,蒲位凌,骆莹莹,白茹玉,史红,周昆,高秀梅,孙力康.丹参雌激素样作用及机制研究近况[J].天津中医药大学学报,2017,36(5):324-328. |
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| 作者姓名： | 郭傲玮 蒲位凌 骆莹莹 白茹玉 史红 周昆 高秀梅 孙力康 |
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| 作者单位： | 天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193,天津中医药大学, 天津市中药药理重点实验室, 天津 300193 |
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| 基金项目： | 天津中医药大学十二五学科师资基金；国家自然基金重点基金（81630106）。 |
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| 摘 要： | 丹参是活血化瘀类常用中药之一,具有活血化瘀、调经、凉血消痈、安神的功效。丹参作为单味药或配伍用药广泛应用于临床。临床以及相关实验研究表明,丹参及其所含有的多种化学成分均有雌激素样作用,可通过调节雌激素受体(ER)、促进细胞凋亡等方式抑制乳腺增生、乳腺癌等妇科疾病的发生发展。
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| 关 键 词： | 丹参 雌激素样作用 作用机制 |
| 收稿时间： | 2017/4/21 0:00:00 |
Advances in mechanism studies on estrogen-like effect of Salvia miltiorrhiza Bge. |
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| GUO Ao-wei,PU Wei-ling,LUO Ying-ying,BAI Ru-yu,SHI Hong,ZHOU Kun,GAO Xiu-mei and SUN Li-kang.Advances in mechanism studies on estrogen-like effect of Salvia miltiorrhiza Bge.[J].Journal of Tianjin University of Traditonal Chinese Medicine,2017,36(5):324-328. |
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| Authors: | GUO Ao-wei PU Wei-ling LUO Ying-ying BAI Ru-yu SHI Hong ZHOU Kun GAO Xiu-mei and SUN Li-kang |
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| Institution: | Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China and Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of pharmacology of Chinese Materia Medica, Tianjin 300193, China |
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| Abstract: | Salvia miltiorrhiza Bge. is a kind of classical traditional Chinese medicine for promoting blood-system circulation by promoting the blood-system circulation to remove blood stasis and to regulate the menstruation, and by cooling the blood-system to remove carbuncle and tranquilization. It''s showed that the pharmacological effects of Salvia miltiorrhiza Bge., in the related experimental research and clinical application. Salvia miltiorrhiza Bge. and its active ingredients were similar to those of phytoestrogens, which were widely used in therapy of gynecological disease, such as breast cancer and hyperplasia of mammary glands, through regulation of ER, promoting cell apoptosis or other pathway. |
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| Keywords: | Salvia miltiorrhiza Bge estrogen-like effect mechanism |
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