| 银杏叶提取物对糖尿病大鼠睾丸和附睾组织自由基和抗氧化水平的影响 |
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| 引用本文： | 徐秋玲,孙卫,郑学芝,刘桂莲,念红.银杏叶提取物对糖尿病大鼠睾丸和附睾组织自由基和抗氧化水平的影响[J].中国全科医学,2009,12(2). |
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| 作者姓名： | 徐秋玲 孙卫 郑学芝 刘桂莲 念红 |
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| 作者单位： | 牡丹江医学院生理教研室,黑龙江省牡丹江市,157011 |
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| 摘 要： | 目的 探讨银杏叶提取物(EGb)对糖尿病大鼠睾丸和附睾组织自由基和抗氧化水平的影响.方法 从40只Wistar雄性大鼠中随机抽取10只作为正常对照组,其余大鼠用链脲佐菌素(STZ)加高脂高糖饮食制备2型糖尿病模型.造模动物筛选后,随机分为糖尿病组和治疗组,每组10只.治疗组给予EGb 10周后,取3组大鼠双侧睾丸和附睾组织.检测丙二醛(MDA)、一氧化氮(NO)水平和超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮合酶(NOS)活性.结果 3组大鼠睾丸、附睾组织中MDA、NO水平及SOD、GSH-Px、NOS活性问差别均有统计学意义(P＜0.01).糖尿病组大鼠睾丸、附睾组织中MDA、NO水平及SOD、GSH-Px和NOS活性与对照组比较,差别均有统计学意义(P＜0.01);治疗组大鼠睾丸组织中MDA水平及SOD、GSH-Px活性与对照组,差别均有统计学意义(P＜0.05);治疗组大鼠附睾组织中MDA水平及SOD、GSH-Px、NOS活性与对照组比较,差别均有统计学意义(P＜0.05);治疗组大鼠睾丸和附睾组织中MDA、NO水平及SOD、GSH-Px和NOS活性与糖尿病组比较,差别均有统计学意义(P＜0.01).结论 银杏叶提取物对糖尿病大鼠睾丸和附睾组织具有保护作用.
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| 关 键 词： | 糖尿病 2型 银杏叶提取物 睾丸 附睾 自由基 |
Effects of Extract of Ginkgo Biloba Leaves on Free Radical and Anti-oxidant Level of Testis and Epididymis Tissues in Diabetic Rats |
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| XU Qiu-ling,SUN Wei,ZHENG Xue-zhi,et al..Effects of Extract of Ginkgo Biloba Leaves on Free Radical and Anti-oxidant Level of Testis and Epididymis Tissues in Diabetic Rats[J].Chinese General Practice,2009,12(2). |
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| Authors: | XU Qiu-ling SUN Wei ZHENG Xue-zhi |
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| Institution: | XU Qiu-ling,SUN Wei,ZHENG Xue-zhi,et al.Department of Physiology,Mudanjiang Medical College,Mudanjiang 157011,China |
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| Abstract: | Objective To observe the effects of extract of Ginkgo biloba leaves on free radical and anti-oxidant of testis and epididymis tissues in diabetic rats.MethodsTen of 40 male Wistar rats were randomly chosen as normal control group,the others were given streptozotocin(STZ) and high-fat and-glucose diet to prepare type II diabetic models,and the prepared models selected were randomly divided into diabetes and treatment groups,10 in each.After the treatment group were treated with ginkgo biloba extract for 10 w... |
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| Keywords: | Diabetes mellitus type 2 Extract of ginkgo biloba leaf Testis Epididymis Free radicals |
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