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| 山茱萸提取部位对D-半乳糖致衰模型小鼠骨髓细胞脱氧核糖核酸的影响 | |
| 引用本文： | 王明艳,江励华,董菊,许冬青,杜逸芳,俞晓忆,杜伟锋,蔡宝昌.山茱萸提取部位对D-半乳糖致衰模型小鼠骨髓细胞脱氧核糖核酸的影响[J].时珍国医国药,2010,21(10). |
| 作者姓名： | 王明艳 江励华 董菊 许冬青 杜逸芳 俞晓忆 杜伟锋 蔡宝昌 |
| 作者单位： | 1. 南京中医药大学,江苏省中药炮制重点实验室,江苏,南京,210029 2. 南京师范大学,江苏,南京,210005 3. 中国药科大学,江苏,南京210009 4. 浙江中医药大学,浙江,杭州,311401 |
| 基金项目： | 国家自然科学基金，国家"十五"科技攻关计划 |
| 摘 要： | 目的 探讨山茱萸几种提取部位对D-半乳糖致衰模型小鼠骨髓细胞DNA的影响.方法 取ICR小鼠,复制D-半乳糖致衰模型,给小鼠灌服药液,通过单细胞电泳和流式细胞仪检测,观察D-半乳糖致衰模型小鼠骨髓细胞DNA的变化及山茱萸几种提取部位的保护作用.结果 D-半乳糖对小鼠骨髓细胞脱氧核糖核酸(DNA)结构表现出一定的的影响,山茱萸几种提取部位尤其是石油醚萃取部位表现出保护作用.结论 山茱萸提取部位对D-半乳糖致衰模型小鼠DNA结构有不同程度的影响. |
| 关 键 词： | 山茱萸 提取部位 D-半乳糖 脱氧核糖核酸 |
Effect of Extracts from Fructus Corni on DNA in Marrow Cells of D-galactose-induced Subacute Aging Mice |
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| WANG Ming-yan,JIANG Li-hua,DONG Ju,XU Dong-qing,DU Yi-fang,YU Xiao-yi,DU Wei-feng,CAI Bao-chang.Effect of Extracts from Fructus Corni on DNA in Marrow Cells of D-galactose-induced Subacute Aging Mice[J].Lishizhen Medicine and Materia Medica Research,2010,21(10). | |
| Authors: | WANG Ming-yan JIANG Li-hua DONG Ju XU Dong-qing DU Yi-fang YU Xiao-yi DU Wei-feng CAI Bao-chang |
| Institution: | WANG Ming-yan1,JIANG Li-hua1,DONG Ju1,XU Dong-qing1,DU Yi-fang2,YU Xiao-yi3,DU Wei-feng4,CAI Bao-chang 1* ( 1. Jiangsu Key Laboratory of Chinese Medicine Processing,Nanjing University of Chinese Medicine,Nanjing,210029,China,2. Nanjing Normal University,210005,3. China Pharmacological University,Nanjing 210009,4. Zhejiang University of Chinese Medicine,Zhejiang,311401,China) |
| Abstract: | Objective To investigate the effect of extracts from Fructus Corni on DNA of marrow cells in D-galactose induced subacute aging mice. Methods The subacute aging model was established by D-galactose induced in ICR mice,and the DNA change was tested by single-cell electrophoresis and flow cytometry detection. Results D-galactose had the effect on DNA of marrow cells of ICR mice and extracts from Fructus Corni,especially the extract of petroleum showed certain protective effects against DNA damage. Conclusion ... |
| Keywords: | Fructus Corni Extract D-galactose DNA |
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