TLR7基因多态性与丙型肝炎病毒感染转归的关系

摘要:目的　探讨TLR7（Toll-Like Receptor 7，）基因多态性与丙型肝炎病毒（Hepatitis C Virus，HCV）感染转归的关系。方法　运用TaqMan-MGB荧光探针法检测1146例健康对照者，299例HCV自限清除者以及410例HCV持续感染者中TLR7多态性位点，比较不同位点基因型与HCV感染转归的关系。结果　在女性人群中，rs179009位点突变基因型GG可增加HCV感染的风险（OR＝2.40，95% CI:1.09～5.27），rs3853839位点突变基因型CC降低HCV感染慢性化的风险（OR＝0.31，95% CI:0.10～0.94）；单倍型AC和GG可显著降低HCV感染慢性化的风险。结论　TLR7基因多态性可能与女性丙型肝炎易感性及慢性化有关。

Study of Polymorphisms of TLR7 with Hepatitis C Virus infection

Abstract: Objective The aim of this study was to estimate the distributions of TLR7 single nucleotide polymorphisms（SNPs）and the susceptibility or the outcomes of HCV infection. Methods To investigate the association of TLR7 single nucleotide polymorphisms in HCV infection subjects, we conducted a case-control study among 1146 uninfected controls, 299 subjects with natural clearance and 410 HCV persistent carriers using Taqman-MGB. Results Between HCV infected subjects（HCV persistent carriers and HCV natural clearance subjects）and uninfected subjects, the variant genotype GG of rs179009 increased the risk of HCV infection among females (OR=2.40, 95% CI=1.09-5.27). Besides, compared with HCV natural clearance subjects carrying GG of rs3853839, those with CC genotype had an decreased risk for chronic infection (OR=0.31, 95% CI=0.10-0.94). The haplotype analysis among females found that haplotype AC and GG were associated with HCV natural clearance (both P<0.05). The CC was not associated with HCV susceptibility and HCV natural clearance (P>0.05). Conclusion This study indicated that two SNPs in TLR7 are associated with HCV clearance and susceptibility to HCV infection.