| 氧自由基致痛、痛敏及其与阿斯匹林、吲哚美辛镇痛的关系 |
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| 引用本文： | 王洁,宋必卫,陈志武,李前进,马传庚,徐叔云.氧自由基致痛、痛敏及其与阿斯匹林、吲哚美辛镇痛的关系[J].中国现代应用药学,1997,14(4):8-11. |
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| 作者姓名： | 王洁 宋必卫 陈志武 李前进 马传庚 徐叔云 |
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| 作者单位： | [1]中国医学科学院药物研究所 [2]安徽医科大学药理教研室 |
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| 摘 要： | 采用光照核黄素产生氧自由基，观察后者在外周和脊髓水平对疼痛的影响。发现在外周，小鼠足跖部皮下注射ＬＲＦ０．０６，０．６７ｍｍｏｌ．ｍｏｕｓｅ＾－１有致痛作用；脊髓水平，小鼠鞘内注射ＬＲＦ０．１０６－０．６６５ｎｍｏｌ．ｍｏｕｓｅ＾－１有致痛敏作用；进一步研究发现ＯＦＲ的脊髓痛敏与Ｃａ＾２＋有密切关系，用维拉帕米，尼莫地平，ＥＧＴＡ可拮抗ＯＦＲ的痛敏作用。
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| 关 键 词： | 氧自由基 阿斯匹林 吲哚美辛 镇痛 |
Studies of the Relationship between the Algesia and Hyperalgesia of OFR and the Analgesia of Aspirin and Indomethacin |
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| Wang Jie;Song Bi-wei; Ma Chuan-gen et al.Studies of the Relationship between the Algesia and Hyperalgesia of OFR and the Analgesia of Aspirin and Indomethacin[J].The Chinese Journal of Modern Applied Pharmacy,1997,14(4):8-11. |
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| Authors: | Wang Jie;Song Bi-wei; Ma Chuan-gen |
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| Abstract: | By 1 ighting riboflavin to produce OFR, we studied the role of OFR in spinal and peripheral pain. Intraplantar injection (ipl) LRP at dose of 0.67 mmol/mice or 0.067mmol/mice in 0ne hind paw could induce peripheral pain. Intrathecal injection (ith) LRF 0.106~0.665nmol/mico could induce spinal hyperalgcsia. More research suggest that calcium might mediate the spinal hyperalgesia of OFR and scavenging PFR might involve itt the analgesia of ASP,IND. |
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| Keywords: | oxygen free radicals Iighted ribotlavin aspirin indomethacin |
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