| 嗅觉受体基因和蛋白的研究进展 |
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| 引用本文： | 彭鹤,赵鲁杭.嗅觉受体基因和蛋白的研究进展[J].浙江大学学报(医学版),2012,41(1):117-122. |
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| 作者姓名： | 彭鹤 赵鲁杭 |
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| 作者单位： | 浙江大学医学院生物化学与分子生物学实验室,浙江杭州,310058 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(31000448) |
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| 摘 要： | 嗅觉感知的起始是由嗅觉受体( olfactory receptor,OR)被气味分子激活,引起细胞内的信号转导,将气味的化学信号转变成电信号,传到更高的脑部结构,完成气味感知.OR基因属于多基因家族,编码的嗅觉受体蛋白(olfactory receptor protein)属于G-蛋白偶联受体超家族,有7个跨膜区域.嗅觉受体蛋白在嗅觉识别气味及信号传导过程中起着重要的作用.
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| 关 键 词： | 嗅觉受体神经元 受体 有气味性物质/遗传学 嗅觉 信号传导 |
Research progress on olfactory receptor |
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| PENG He
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ZHAO Lu-hang.Research progress on olfactory receptor[J].Journal of Zhejiang University(Medical Sciences),2012,41(1):117-122. |
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| Authors: | PENG He ZHAO Lu-hang |
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| Institution: | Department of Biochemistry and Molecular Biology, Zhejiang University School of Medicine, Hangzhou 310058, China. |
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| Abstract: | The olfactory perception is the process that the olfactory receptor is activated by odorous molecules, which induce the transduction of signal in the cell and the chemical information is transduced into electrical impulses. After the changed signal is transmitted to the brain, the whole perception process completes. OR gene belongs to the multigene family. The coded olfactory receptor proteins belong to the G-protein-coupled receptor (GPCR) superfamily and therefore are invariably seven-transmembrane domain(7TM) protein. Olfactory receptor protein plays an important role in olfactory perception and signal transduction process. |
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| Keywords: | Olfactory receptor neurons Receptors odorant/genetics Smell Signal transduction |
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