阿魏酸哌嗪片对伴心血管危险因素老年COPD患者血管内皮功能、颈动脉斑块性质及心肺功能的影响

观察阿魏酸哌嗪片对伴心血管危险因素老年慢性阻塞性肺疾病(COPD)患者血管内皮功能、颈动脉斑块性质及心肺功能的影响。将100例伴心血管危险因素老年COPD患者分为对照组(n=50)和观察组(n=50),对照组采用常规药物治疗,观察组在常规药物治疗基础上加用阿魏酸哌嗪片。结果显示:治疗后两组心功能指标、肺功能指标、血管功能指标、颈动脉斑块指标均有所改善,且观察组改善程度优于对照组(P<0.05)。老年人的颈动脉斑块发生与心血管危险因素有关,阿魏酸哌嗪片治疗老年慢性阻塞性肺疾病能够有效改善心肺功能及血管内皮功能,稳定、改善颈动脉斑块,具有较好的临床疗效。

Effects of piperazine ferulate tablets on vascular endothelial function, carotid artery plaque and cardiopulmonary function in elderly patients with COPD associated with cardiovascular risk factors

The effects of piperazine ferulic acid tablet on vascular endothelial function, carotid plaque properties and cardiopulmonary function in elderly patients with chronic obstructive pulmonary disease (COPD) with cardiovascular risk factors were compared. 100 cases of elderly COPD patients with cardiovascular risk factors were divided into the control group (n=50) and the observation group (n=50). The control group was treated with conventional drug therapy, and the observation group was treated with piperazine ferulose on the basis of conventional drug therapy. Compared with before treatment, cardiac function indexes, pulmonary function indexes, the vascular function indexes, the carotid plaque indicators of both groups were improved after treatment, and the improvement degree in the observation group was better than that in the control group (P<0.05). Therefore, the occurrence of cervical artery plaque in the elderly is related to cardiovascular risk factors. Piperazine ferulic acid tablet for the treatment of chronic obstructive pulmonary disease in the elderly can effectively improve cardiopulmonary function and vascular endothelial function, stabilize and improve cervical artery plaque, and has a good clinical efficacy, which is worthy of further promotion in clinical practice.