藏药肉果草中1对新的木脂素苷

目的 研究肉果草Lancea tibetica的化学成分。方法 综合应用硅胶、Sephadex LH-20和制备液相等多种色谱方法进行分离纯化，并根据化合物NMR谱、MS谱等数据进行结构鉴定。采用斑马鱼炎症模型进行抗炎活性评价。结果 从肉果草乙醇提取物的醋酸乙酯萃取部位中分离得到1对新的四氢呋喃型木脂素苷类化合物（1a和1b）和已知化合物肉果草苷（2）。结论 化合物1a和1b为新化合物，是1对能发生差向异构的、不可分的化合物，分别命名为肉果草苷A(1a)、肉果草苷B(1b)，且具有抗炎活性。

A pair of new lignan glycosides from Tibetan medicine Lancea tibetica

Objective To study the chemical constituents of Lancea tibetica. Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20 column chromatography and preparative RP-HPLC. Their structures were elucidated by analysis of NMR and HR-ESI-MS spectroscopic data. Zebrafish model was used to evaluate the anti-inflammatory activity of compounds. Results A pair of new tetrahydrofuran-type lignan glycosides (1a and 1b) and a known compound (tibeticoside) were isolated from the EtOAc-soluble partition of the aqueous ethanolic extract of L. tibetica. Conclusion Compounds 1a and 1b are new compounds, a pair of epimeric and indivisible compounds, named (7R,8R,8''S,9''S)-9''-hydroxyl tibeticoside and (7R,8R,8''S,9''R)-9''-hydroxyl tibeticoside, respectively. And compound 1 shows anti-inflammation activity.