| 鹿茸多胺的抗脂质过氧化作用 |
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| 引用本文： | 陈晓光,金淑莉,邸琳,刘新宇,张晓宇.鹿茸多胺的抗脂质过氧化作用[J].中草药,2004,35(8):901-904. |
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| 作者姓名： | 陈晓光 金淑莉 邸琳 刘新宇 张晓宇 |
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| 作者单位： | 1. 吉林省中医中药研究院,药理室,吉林,长春,130021
2. 长春公交医院,吉林,长春,130021 |
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| 摘 要： | 目的 研究鹿茸多胺的抗氧化作用。方法 测定鹿茸多胺在体外对NADPH-维生素C和Fe^2 半胱氨酸系统诱发的微粒体脂质过氧化反应(MDA形成)的影响，对黄嘌呤-黄嘌呤氧化酶系统超氧阴离子自由基(O2^-)产生(还原型细胞色素C形成)的影响，在体内对CCI。和乙醇诱发的小鼠肝脂质过氧化反应(MDA形成)的影响。结果 鹿茸多胺在体外能明显抑制NADPH-维生素C和Fe^2 一半胱氨酸系统诱发的大鼠脑、肝、肾微粒体脂质过氧化反应(MDA形成)，及黄嘌呤一黄嘌呤氧化酶系统O2^-的产生(还原型细胞色素C形成)。在体内能抑制CCl4和乙醇诱发的小鼠肝脂质过氧化反应(MDA形成)。结论 鹿茸多胺具有抗氧化作用。
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| 关 键 词： | 鹿茸 多胺 脂质过氧化 超氧阴离子自由基 |
| 收稿时间： | 2003/11/19 0:00:00 |
Antilipid peroxidation of polyamines from pilose antler |
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| CHEN Xiao-guang,JIN Shu-li,DI Lin,LIU Xin-yu and ZHANG Xiao-yu.Antilipid peroxidation of polyamines from pilose antler[J].Chinese Traditional and Herbal Drugs,2004,35(8):901-904. |
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| Authors: | CHEN Xiao-guang JIN Shu-li DI Lin LIU Xin-yu and ZHANG Xiao-yu |
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| Institution: | Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021, China;Hospital of Changchun Public Traffic Company, Changchun 130021, China;Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021, China;Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021, China;Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021, China |
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| Abstract: | Object To investigate the antioxidant activity of polyamines isolated from pilose antler (PAIPA). Methods The effects of PAIPA on the lipid peroxidation (MDA formation) in microsomes of rat brain, liver, and kidney induced by NADPH-Vitamine C (Vc) and ferrous-cysteine systems in vitro, the superoxide anion radical production (reduced cytochrome C formation) in xanthine-xanthine oxidase system in vitro, and the CCl 4-and ethanol-induced MDA formation in mice liver in vivo were evaluated. Results PAIPA could significantly inhibit the lipid peroxidation (MDA formation) i n microsomes of rat brain, liver, and kidney induced by NADPH-Vc and ferrous-c yctein, the superoxide anion radical production (formation of reduced cytochrome C) in xanthine-xanthine oxidase system in vitro, and the CCl 4- and ethanol-induced MDA formation in mice liver in vivo. Conclusion PAIPA exhibits an antioxidant activity. |
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| Keywords: | pilose antloer polyamines lipid peroxidation superoxide anion radical |
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