| 黄金血康预防兔高脂血症和动脉粥样硬化 |
| |
| 引用本文： | 赵益明,张威,何杨,沈文红,阮长耿.黄金血康预防兔高脂血症和动脉粥样硬化[J].苏州大学学报(自然科学版),2008,28(5). |
| |
| 作者姓名： | 赵益明 张威 何杨 沈文红 阮长耿 |
| |
| 作者单位： | 苏州大学附属第一医院,江苏省血液研究所,江苏苏州215006 |
| |
| 基金项目： | 苏州大学校科研和教改项目 |
| |
| 摘 要： | 目的研究黄金血康对兔高脂血症和动脉粥样硬化形成的调节和预防作用。方法将实验兔分成正常对照组、动脉粥样硬化模型组和黄金血康预防组,分别喂普通饲料、高脂饲料和高脂饲料加黄金血康。2周后,所有的实验动物分别用气囊损伤兔腹主动脉内皮细胞,分别于实验前和实验第4、8、12周进行兔静脉采血,测定血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白AI（apoAI）和载脂蛋白B（apoB）的水平。结果模型组与对照组相比,其血清TC、TG显著升高,差异有高度统计学意义（P〈0.01）;预防性给药组与模型组相比,兔血清TC、TG、apoB降低,差异有统计学意义（P〈0.05或〈0.01）;而HDL-C、apoAI升高,差异有统计学意义（P〈0.05或〈0.01）。结论黄金血康对高脂血症兔脂质具有明显的调节作用,提示此药具有抗动脉粥样硬化形成的作用。
|
| 关 键 词： | 黄金血康 高脂血症 动脉粥样硬化 预防 兔 动物模型 |
Preventive Effects of Huangjin Xuekang on Experimental Hyperlipidemic and Atherogensis of Rabbits |
| |
| ZHAO Yi-ming,ZHANG Wei,HE Yang,SHEN Wen-hong,RUAN Chang-geng.Preventive Effects of Huangjin Xuekang on Experimental Hyperlipidemic and Atherogensis of Rabbits[J].Suzhou University Journal of Medical Science,2008,28(5). |
| |
| Authors: | ZHAO Yi-ming ZHANG Wei HE Yang SHEN Wen-hong RUAN Chang-geng |
| |
| Institution: | ZHAO Yi-ming,ZHANG Wei,HE Yang,SHEN Wen-hong,RUAN Chang-geng (Jiangsu Institute of Hematology,the First Hospital Affiliated to Soochow University,Jiangsu Suzhou 215006,China) |
| |
| Abstract: | Objective To investigate the preventive effects of Huangjin Xuekang (HJXK) against experimental hyperlipidemic and atherogensis (AS) of rabbits. Methods Twenty four healthy New Zealand white rabbits were randomly divided into three groups. Rabbits were fed with normal food in the control group, with high fat diet in the model group, and with high fat diet and HJXK in the preven- tion group. All experimental rabbits underwent hurt to endomembrane of abdominal aorta with the same method. Serum total cholester... |
| |
| Keywords: | huangjin xuekang hyperlipidemic atherogensis preventive rabbit animal model |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
