| 茶多酚抗移植性乳腺癌作用的研究 |
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| 引用本文： | 张燕明,徐力,陈信义.茶多酚抗移植性乳腺癌作用的研究[J].国际中医中药杂志,2006,28(6):354-356,384. |
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| 作者姓名： | 张燕明 徐力 陈信义 |
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| 作者单位： | 1. 100700,北京,北京中医药大学东直门医院肿瘤血液科
2. 210029,南京,南京中医药大学科研处 |
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| 基金项目： | 国家自然科学基金，编号：30472280 |
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| 摘 要： | 目的观察茶多酚对移植性小鼠乳腺癌(EMT_6)生长的抑制作用,为进一步开展茶多酚抗肿瘤新生血管形成研究提供依据。方法小鼠可移植性乳腺癌(EMT_6)细胞系经传代培养后,对纯系BALB/c小鼠进行肿瘤移植,以茶多酚进行干预性治疗,通过抑瘤率评价茶多酚对EMT_6生长的抑制作用。结果茶多酚灌胃和局部注射组对EMT_6的抑瘤率分别为37．43%、40．94%。结论茶多酚对EMT_6生长具有明显的抑制效果。
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| 关 键 词： | 茶多酚 乳腺癌(EMT_6) 肿瘤抑制作用 |
| 收稿时间： | 2006-08-15 |
| 修稿时间： | 2006-08-15 |
Anticancer effect of tea polyphenols on implanted breast cancer |
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| ZHANG Yan-ming,XU Li,CHEN Xin-yi.Anticancer effect of tea polyphenols on implanted breast cancer[J].International Journal of Traditional Chinese Medicine,2006,28(6):354-356,384. |
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| Authors: | ZHANG Yan-ming XU Li CHEN Xin-yi |
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| Institution: | Neoplastic Hematology Department of Dongzhimen Hospital, Beijing University oJ Traditional Chinese Medicine, Beijing 100700, China |
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| Abstract: | Objective To observe the growth inhibiting effect of tea polyphenols on implanted mouse breast cancer(EMT_6),and offer the foundation for the next study on its inhibiting angiogenesis effect and its molecular mechanism.Methods Mammary adenocarcinoma EMT_6 was cultured and propagated,then implanted on female BALB/c mice.Tea polyphenols was peroral administrated and local injected.Anticancer function was determined with regular methods.Result After tea polyphenols were taken by oral and local injection on EMT_6 mammary adenocarcinoma mice,the inhibitory ratio of tumor are respectively 37.43% and 40.94%.Conclusion Tea polyphenols had significant inhibitive effect on implanted breast cancer.This offered the foundation for the next intensiVe study on its inhibiting angiogenesis effect and its molecular mechanism. |
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| Keywords: | Tea polyphenols Breast cancer (EMT6) Antitumor effect |
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