虚秘通方治疗气虚型功能性便秘的临床疗效观察

【目的】观察虚秘通方治疗气虚型功能性便秘的临床疗效。【方法】将60例气虚型功能性便秘患者随机分为治疗组和对照组,每组各30例。治疗组给予虚秘通方治疗,对照组给予缓泻剂乳果糖口服液治疗,疗程为4周,并于疗程结束4周后进行随访。观察2组患者治疗前后中医证候积分、便秘患者生活质量量表(PAC-QOL)评分的变化情况,评价2组患者的中医证候疗效和复发情况。【结果】(1)证候疗效方面:治疗4周后,治疗组的总有效率为90.0%(27/30),对照组为73.3%(22/30);组间比较,治疗组的中医证候疗效明显优于对照组(P<0.05)。(2)证候积分方面:治疗后,2组患者的中医证候积分均较治疗前明显下降(P<0.01),但2组治疗后比较,差异无统计学意义(P>0.05)。(3)生活质量方面:治疗后,2组患者的PAC-QOL评分均较治疗前明显下降(P<0.01),且治疗组对PAC-QOL评分的下降作用明显优于对照组(P<0.05)。(4)复发情况方面:治疗结束4周后,治疗组的复发率为19.2%(5/26),对照组为52.4%(10/21);组间比较,治疗组的复发率明显低于对照组(P<0.05)。【结论】虚秘通方治疗气虚型功能性便秘疗效显著,不仅能显著改善患者便秘的各项症状,还能改善患者的生活质量和控制便秘的复发。

Clinical Effect of Xumi Tong Formula in the Treatment of Functional Constipation of Qi Deficiency Type

Objective To observe the clinical effect of Xumi Tong Formula in treating functional constipation of qi deficiency type. Methods Sixty patients with functional constipation of qi deficiency type were randomly divided into the treatment group and the control group,with 30 cases in each group. The treatment group was treated with Xumi Tong Formula orally,and the control group was treated with laxative lactulose oral liquid orally. The course of treatment lasted for 4 weeks, and the patients were followed up after 4 weeks of treatment. The traditional Chinese medicine(TCM)syndrome scores and the patient assessment of constipation-quality of life(PAC-QOL)scores in the two groups were observed before and after treatment. After treatment,the TCM syndrome efficacy and recurrence of constipation in the two groups were evaluated. Results(1)Syndrome efficacy: after 4 weeks of treatment,the total effective rate of the treatment group was 90.0%(27/30),and that of the control group was73.3%(22/30). The TCM syndrome efficacy in the treatment group was significantly superior to that in the control group(P<0.05).(2)Syndrome scores: after treatment, TCM syndrome scores of both groups were decreased significantly compared with those before treatment(P<0.01),but there was no statistical significance between the two groups after treatment(P>0.05).(3)Quality of life:after treatment,PAC-QOL scores in both groups were decreased significantly compared with those before treatment(P<0.01),and the effect on decreasing PAC-QOL scores in the treatment group was significantly superior to that in the control group(P<0.05).(4)Recurrence:at the end of 4-week treatment,the recurrence rate of constipation in the treatment group was 19.2%(5/26)and that of the control group was 52.4%(10/21). The intergroup comparison showed that the recurrence rate in the treatment group was significantly lower than that in the control group(P<0.05). Conclusion Xumi Tong Formula exerts significant effect in the treatment of functional constipation with qi deficiency type,which can not only significantly relieve the symptoms of constipation,but also improve the quality of life of the patients and reduce the recurrence of constipation.