| 幽门螺杆菌致病机制的研究进展 |
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| 引用本文： | 王美芬,黄永坤,李海林.幽门螺杆菌致病机制的研究进展[J].医学综述,2006,12(8):468-471. |
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| 作者姓名： | 王美芬 黄永坤 李海林 |
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| 作者单位： | 昆明医学院第一附属儿科,昆明,650032 |
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| 摘 要： | 幽门螺杆菌(HP)是世界各地最常见的感染性病原之一,目前认为HP感染是慢性胃炎、消化性溃疡、胃MALT淋巴瘤、胃腺癌的主要病因,世界卫生组织将其归为一类致癌因子。但HP感染引起的人类胃肠疾病机制尚不清楚,可能与细菌毒力的高低尤其是HP基因多态性、细菌引起的炎症及免疫反应与宿主的免疫遗传等因素有关。
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| 关 键 词： | 幽门螺杆菌 感染 机制 多态性 |
| 文章编号： | 1006-2084（2006）08-0468-04 |
| 收稿时间： | 2005-09-06 |
| 修稿时间： | 2006-02-04 |
The Progress of Pathogenic Mechanism of Helicobacter Pylori Infection |
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| WANG Mei-fen,HUANG Yong-kun,LI Hai-lin.The Progress of Pathogenic Mechanism of Helicobacter Pylori Infection[J].Medical Recapitulate,2006,12(8):468-471. |
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| Authors: | WANG Mei-fen HUANG Yong-kun LI Hai-lin |
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| Institution: | The Department of Pediatrics the First Affiliated Hospital, Kunming Medical College, Kunming 650032, China |
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| Abstract: | Helicobacter Pylori(HP) is one of the most common infection bacteria in the world.At present,HP infection is regarded as the main reasons of chronic gastritis,peptic ulcer,gastric MALT lymphoma and gastric adenocarcinoma.World Health Organization has been classfied HP as the first carcinogenic factor.But the mechanism of gastroenteric disease caused by HP is still unclear.It might possibly associate with its bacterial virulence,especially with polymorphism of HP gene、inflammatory and immune response caused by bacteria and host immunogenetic factors and so on. |
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| Keywords: | Helicobacter pylori Infection Mechanism Polymorphism |
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