碱性成纤维细胞生长因子与转化生长因子β在近视眼巩膜中作用的研究进展

近视是世界最常见眼病之一，其发病机制尚不完全清楚。有研究发现，细胞生长因子与近视的发生发展密切相关，其中碱性成纤维细胞生长因子（bFGF）与转化生长因子β（TGF-β）作为关键的信号分子可以通过调控巩膜细胞外基质的合成与降解参与近视眼巩膜重塑，但具体转导途径和机制还不十分清楚。现就bFGF和TGF-β在近视眼巩膜中的表达及其调控巩膜重塑的可能机制进行综述。

Progress in research on basic fibroblast growth factor and transforming growth factor-β in the myopic sclera

Myopia is one of the most common human eye diseases but its pathogenesis is still unclear. In recent years， several researchers have indicated that there are a variety of cell growth factors relating to the occurrence and development of myopia. Basic fibroblast growth factor （bFGF） and transforming growth factor-β （TGF-β） are important signaling molecules that could regulate myopic sclera remodeling by controlling the synthesis and degradation of the scleral extracellular matrix. However， further study about the specific pathways and mechanisms remains to be done. This review summarizes the expression in myopic sclera and the possible contributions of bFGF and TGF-β in regulating scleral remodeling.