| 大黄总甙、大黄素和番泻甙对小鼠离体肠管葡萄糖转运电位的影响 |
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| 引用本文： | 崔志清,郭世铎,李淑华.大黄总甙、大黄素和番泻甙对小鼠离体肠管葡萄糖转运电位的影响[J].中国药理学通报,1992(4). |
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| 作者姓名： | 崔志清 郭世铎 李淑华 |
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| 作者单位： | 天津医学院药理教研室，天津医学院药理教研室，通辽卫校药理教研室 300070，300070 |
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| 摘 要： | 本实验采用记录翻转小肠和结肠囊葡萄糖转运电位的方法,来研究大黄泻下作用的有效成分大黄总甙、大黄素和番泻甙对小肠及结肠囊跨肠壁电应差的变化,发现上述成分可阻止葡萄糖和Na~+的转运,这一结果为进一步阐明大黄泻下作用的原理提供新的理论依据。
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| 关 键 词： | 大黄总甙 大黄素 葡萄糖 跨肠壁电位差 |
The effect of total glycoside of Rhubarb, Emodin and Sennosides on transmural potential of mouse intestine in vitro |
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| GUI Zhi - Qing,GUO Shi -Duo,Li Shu-Hua.The effect of total glycoside of Rhubarb, Emodin and Sennosides on transmural potential of mouse intestine in vitro[J].Chinese Pharmacological Bulletin,1992(4). |
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| Authors: | GUI Zhi - Qing GUO Shi -Duo Li Shu-Hua |
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| Abstract: | The electrical potential difference (PD) was measured across the wall of reverted intestinal sacs. The effect of the effective component of Rhubarb on transmural potential related to Na+ and glucose transport were investigated. It was found that total glucoside of Rhubarb, Emodin and Sen-nosides decreased the PD. The experimental resuilts provide new scientific basis for explaining the mechanism of Rhubarb's purgative action. |
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| Keywords: | Total glycoside of Rhubarb Emodin Sennosides Glucose Transmural potential difference |
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