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| miR-34b/c启动子区多态性与原发性肝细胞肝癌易感性的关联研究 | |
| 引用本文： | 刘莉,陈小军,徐妍,董静,刘继斌,胡志斌,沈洪兵.miR-34b/c启动子区多态性与原发性肝细胞肝癌易感性的关联研究[J].疾病控制杂志,2011,15(7):551-554. |
| 作者姓名： | 刘莉 陈小军 徐妍 董静 刘继斌 胡志斌 沈洪兵 |
| 作者单位： | 1. 南通市肿瘤医院内科,江苏,南通,226361;南京医科大学公共卫生学院流行病与卫生统计学系,江苏,南京,210029;南京医科大学第二附属消化医学中心,江苏,南京,210011 2. 南通市肿瘤医院内科,江苏,南通,226361 3. 南京医科大学公共卫生学院流行病与卫生统计学系,江苏,南京,210029 4. 南京医科大学公共卫生学院流行病与卫生统计学系,江苏,南京,210029;南京医科大学肿瘤中心,江苏,南京,210029 |
| 基金项目： | 国家自然科学基金(30800946); 霍英东教育基金会高等院校青年教师基金(122031); 江苏省卫生厅2009年面上项目(H200957); 江苏省333工程项目(DG216D5023) |
| 摘 要： | 目的探讨miR-34b/c rs4938723 T>C与中国人群原发性肝细胞肝癌(hepatocellular carcinoma,HCC)易感性的关系。方法采用病例对照研究设计,选取501例原发性肝细胞肝癌病例和548例正常对照。选取miR-34b/c rs4938723 T>C为研究位点,以聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法进行多态性检测,应用Logistic回归计算OR值及95%CI,比较不同基因型与HCC发病风险的关系。结果在调整年龄、性别、吸烟、饮酒因素后,携带rs4938723 TC/CC基因型者与携带rs4938723 TT基因型个体相比,发生肝癌的风险增加了40%(调整OR=1.40,95%CI=1.10～1.80)。进一步分析显示在原发性肝细胞肝癌的发生中rs4938723基因型与饮酒存在交互作用(相乘交互作用P=0.049,相加交互作用P=0.012)。结论本研究表明位于miR-34b/c启动子区的rs4938723 T>C多态性可能影响中国人群原发性肝细胞肝癌发病风险。 |
| 关 键 词： | 启动区(遗传学) 多态性 单核苷酸 癌 肝细胞 疾病易感性 |
A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma |
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| LIU Li,CHEN Xiao-jun,XU Yan,DONG Jing,LIU Ji-bin,HU Zhi-bin,SHEN Hong-bing.A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma[J].Chinese Journal of Disease Control and Prevention,2011,15(7):551-554. | |
| Authors: | LIU Li CHEN Xiao-jun XU Yan DONG Jing LIU Ji-bin HU Zhi-bin SHEN Hong-bing |
| Institution: | LIU Li1,2,3,CHEN Xiao-jun1,XU Yan2,DONG Jing2,LIU Ji-bin1,HU Zhi-bin2,4,SHEN Hong-bing2,4.1.Department of Internal Medicine,Nantong Tumor Hospital,Nantong 226361,China,2.Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing 210029,3.Institute of Digestive Endoscopy and Medical Center for Digestive Diseases,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,4.Cancer Center |
| Abstract: | Objective To investigate the associations between miR-34b/c rs4938723 T>C and hepatocellular carcinoma(HCC) susceptibility in a Chinese population.Methods A case-control study among 501 HCC cases and 548 controls matched by age and sex was conducted,and the genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) assays.Logistic regression analysis was used to evaluate the odd ratios(ORs) and 95% confidence intervals(CIs) of rs4938723 T>C with susceptibil... |
| Keywords: | Promoter regions(genetics) Polymorphism single nucleotide Carcinoma hepatocellular Disease susceptibility |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |