颅脑损伤患者急性期血液中炎性因子的变化及意义

目的 颅脑损伤是神经外科的常见病症,具有死亡率较高的特定.该研究探讨了急性颅脑损伤患者外周血中的炎性因子的变化及其意义.方法 选择2009年1月～2010年12月在该院神经外科住院治疗的颅脑损伤急性期患者共150例为研究对象,在入院时,以及入院后1、3、5和7d时抽取外周血并检测IL-2、IL-10、TNF-α和CRP进行统计分析.结果 笔者发现CRP水平和TNF-α水平都和损伤程度相关.此外,CRP水平和TNF-α水平也都可以预示疾病的转归.结论 CRP水平和TNF-α水平和颅脑损伤的病情与进展相关,可以作为判断预后情况的指标.

Acute craniocerebral injury and inflammation factors

【Objective】 The present investigation was focused on the relationship between different inflammation factors and acute craniocerebral injury.【Methods】 150 acute craniocerebral injury patients and 50 healthy people in our hospital were collected as experiment sample.At the point of hospitalization and 1,3,5,7 days after treatment,patients peripheral blood sample were collected for detecting IL-2,IL-10,TNF-α and CRP level.【Results】 The present study found at the point of hospitalization,the CRP and TNF-α level were both related with the severe degree of acute injury,while after 7 days of hospitalization,the CRP level would decrease in all group but also appeared different level with injury severe extent.【Conclusions】 CRP and TNF-α level could both be the predict factor for the treatment of acute injury.