| Antigenicity of the HCV HVR1 Peptide Analyzed by Computer Modeling |
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| 作者姓名： | 郑宇 苏琴 林芳 赵军 何卫平 李伯安 李静 高蓉 程云 |
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| 作者单位： | Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China，Department of Immunology，Institute of Infectious Disease，302 Hospital of People′s Liberation Army，Beijing 100039，China |
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| 基金项目： | This study was supported by 95 military program ( No. 96M174，98Z089) |
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| 摘 要： | It is important to develop the HCV vaccines in China, be cause 11% 14% of patients with acute and choric hepati tis in this country are infected by HCV, and most of themare infected with Ⅱ/1b and Ⅲ/2a1]. There are evi dences to indicate that a high variable region 1 (HVR1)exists in the terminal of E2 protein and contains some lin ear epitopes of B cells. Anti HCV antibodies can protectthe sensitive cells from infection by HCV2 4]. We in tended to get some evidences for designing so…
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| 关 键 词： | 抗原性 HCV HVR1 缩氨酸 计算机模型 淋巴细胞 丙肝 高变区 基因多肽 |
Antigenicity of the HCV HVR1 Peptide Analyzed by Computer Modeling |
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| Abstract: | To find out the protective polypeptide epitopes of HCV HVR1, the antigenicity of the synthetic peptide was predicted by computer modeling and verified by ELISA and lymphocyte transformation test. It was found that the outcome of the computer modeling was in accord with the experimental results. The method by using computer modeling would be a economic approach by which the protective peptides could be identified quickly. |
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| Keywords: | Computer modeling Protective peptide Epitope Antigenicity |
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