| 慢性乙型肝炎的抗病毒研究进展 |
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| 引用本文： | 操跃,钱其军.慢性乙型肝炎的抗病毒研究进展[J].药学实践杂志,2015,33(6):561-565. |
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| 作者姓名： | 操跃 钱其军 |
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| 作者单位： | 福建医科大学第一临床医学院, 福建 福州 350108;第二军医大学附属东方肝胆外科医院肿瘤生物治疗科、病毒基因治疗实验室, 上海 200438,第二军医大学附属东方肝胆外科医院肿瘤生物治疗科、病毒基因治疗实验室, 上海 200438 |
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| 摘 要： | 慢性乙型肝炎是由乙型肝炎病毒(hepatitis B virus,HBV)引起的全球性传染病,HBV感染是我国肝硬化、原发性肝癌的重要原因。目前,干扰素类与核苷(酸)类似物抗病毒药物已广泛应用于临床,在一定程度上抑制了病毒的复制并控制了疾病的发展,但仍未从根本上清除病毒;各种治疗性疫苗在抗HBV方面也取得了一定疗效,但临床效果不佳。目前不少研究结果表明,生物免疫治疗可以成功清除体内的HBV,从而为乙肝的治疗带来新的希望。
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| 关 键 词： | 乙型肝炎病毒 核苷酸类似物 干扰素 治疗性疫苗 生物免疫疗法 |
| 收稿时间： | 2015/2/10 0:00:00 |
| 修稿时间： | 2015/7/13 0:00:00 |
Progress in study of antiviral effect of chronic hepatitis B |
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| CAO Yue and QIAN Qijun.Progress in study of antiviral effect of chronic hepatitis B[J].The Journal of Pharmaceutical Practice,2015,33(6):561-565. |
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| Authors: | CAO Yue and QIAN Qijun |
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| Institution: | First Clinical Medical College, Fujian Medical University, Fuzhou 350108, China;Laboratory of Gene and Viral Therapy, Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University, Shanghai 200438, China and Laboratory of Gene and Viral Therapy, Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University, Shanghai 200438, China |
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| Abstract: | Chronic hepatitis B is a worldwide infectious diseases caused by hepatitis B virus (HBV). HBV infection is an important reason for liver cirrhosis and liver cancer in our country. Currently, the interferon and nucleoside analogs antiviral drugs (nucleotides) is widely used in clinical practice. These drugs inhibit the replication of the virus and disease development to a certain extent, but not fundamentally eliminate the virus. Various therapeutic vaccines have also made certain curative effect in anti HBV, but the effect is not perfect clinically. At present, many research Results demonstrate that biological immunotherapy can successfully eliminate HBV virus in the body, therefore it has brought a new hope for the treatment of hepatitis B. |
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| Keywords: | hepatitis B virus nucleoside analogues interferons therapeutic vaccines biological immunotherapy |
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