| 连接黏附分子-1与动脉粥样硬化 |
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| 引用本文： | 李东娟,王家富,李伟.连接黏附分子-1与动脉粥样硬化[J].医学综述,2006,12(17):1029-1030. |
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| 作者姓名： | 李东娟 王家富 李伟 |
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| 作者单位： | 泰山医学院病理学教研室,山东,泰安,271000 |
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| 摘 要： | 连接黏附分子-1是一细胞黏附分子,免疫球蛋白超家族成员,可作为血小板受体参与血小板的活化;作为配基与淋巴细胞功能性抗原结合,促进白细胞的迁移;并参与碱性成纤维细胞生长因子介导的信号转导途径,增强内皮细胞黏附迁移,促进血管新生。连接黏附分子-1参与动脉粥样硬化发生、发展及转归中与内皮细胞有关的多个作用机制,对探讨动脉粥样硬化的防治具有一定的作用。
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| 关 键 词： | 连接黏附分子-1 动脉粥样硬化 血小板 内皮细胞 |
| 文章编号： | 1006-2084（2006）17-1029-02 |
| 收稿时间： | 2006-02-28 |
| 修稿时间： | 2006-07-20 |
Junctional Adhesion Molecule-1 and Atherosclerosis |
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| LI Dong-juan,WANG Jia-fu,LI Wei.Junctional Adhesion Molecule-1 and Atherosclerosis[J].Medical Recapitulate,2006,12(17):1029-1030. |
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| Authors: | LI Dong-juan WANG Jia-fu LI Wei |
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| Abstract: | Junctional adhesion molecule-1 is a cell adhesion molecule belonging to immunoglobulin superfamily. It can not only act as a platelet receptor to participate in platelet activation,but also act as ligand to bind functional antigen of lymphocyte and then promote leukocytal migration . It also participate in the signal transduction mediated by basic fibroblast growth factor to intensify the adhension and migration of endothelial cell as well as to promote vessel neogenesis . Junctional adhesion molecule-1 contributes to several mechanisms about atherosclerosis in its genesis, development and prognosis related to endothelium, which then will be helpful to study the prevention and treatment of atheroselerosis. |
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| Keywords: | Junctional adhesion molecule-1 Atherosclerosis Platelet Endothelial cell |
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