血清肝细胞生长因子水平与冠状动脉粥样硬化的关系

目的:探讨不同类型冠心病患者血清肝细胞生长因子(HGF)水平的临床意义,以及与血管性假血友病因子(vWF)、高敏C-反应蛋白(hs-CRP)的关系.方法:采用ELISA双抗体夹心法测定急性心肌梗死(AMI,24例)、不稳定型心绞痛(UA,23例)、稳定型心绞痛(SA,22例)、健康对照者(20例)血清HGF、vWF和hs-CRP水平.结果:AMI组、UA组急性阶段血清HGF、vWF、hs-CRP显著高于SA组和正常人组(均P＜0.05),后两者之间无显著差异.AMI与UA组患者病情稳定后,血清HGF、hs-CRP、vWF水平较急性阶段显著下降(P＜0.05),与正常人组无显著差异(P＞0.05).AMI与UA组患者急性阶段血清HGF、hs-CRP与vWF之间存在正直线相关关系.结论:研究结果提示HGF作为特异的内皮细胞损伤修复因子,在急性冠状动脉粥样硬化病变时血清水平明显增高,可能与血管内皮功能障碍和炎症反应有关.

The Relation of Serum Hepatocyte Growth Factor and Coronary Atherosclerosis

Objective: To investigate the changes of serum hepatocyte growth factor (HGF) , von Willebrand Factor (vWF), and high sensitive C - reactive protein (hs - CRP) concentrations in various types of coronary heart disease, and clarify their clinical significances. Methods: Sixty - nine patients with ischemic heart disease were included and allocated into 3 groups based on the findings of coronary angiography: stable angina pectoris group (SA, n = 22), unstable angina pectoris group (UA, n = 23), as well as acute myocardial infarction group (AMI, n = 24). Twenty obvious healthy subjects (according to the results of routine laboratory test, physical examination, and coronary angioplasty) were included in this study as control group. The levels of HGF, vWF and hs - CRP were measured by using ELISA. Results: The serum levels of HGF, vWF and hs - CRP in acute phase of UA and AMI increased statistically when compared with those in controls and SA (P < 0.05 to 0.01) .There were no significant differences between controls and SA. The serum levels of HGF, vWF and hs - CRP in stable phase of UA and AMI decreased significantly when compared with those in acute phase of diseases (P < 0.05 to 0.01) . There were no significant differences between stable phase of those and controls (P > 0.05). The serum level of HGF was correlated with the serum level of vWF in patients with acute coronary syndrome (r = 0.62,P<001), and the linear equation was: Y = 85. 83 + 138.22X. The serum level of HGF was correlated with the serum level of hs - CRP in patients with acute coronary syndrome (r=0.62, P<0.01), and the linear equation was: Y= -1.12+ 11.46X. The serum level of vWF was correlated with the serum level of hs - CRP in patients with acute phase of UA and AMI (r = 0.70,P<0.01), and the linear equation was: Y= 116. 85+ 8.44X. Concllision: It was suggested that the serum levels of HGF, as a specific endothelial cell injury and restore factor, in acute phase of the pathophysiologic process increased, which may be rekted to the endothelial injury and inflammation reaction.