| 茶多酚对红细胞膜脂质过氧化损伤的保护作用 |
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| 引用本文： | 陈小夏,何冰,张健泓.茶多酚对红细胞膜脂质过氧化损伤的保护作用[J].中国中医基础医学杂志,1999,5(8):28-31. |
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| 作者姓名： | 陈小夏 何冰 张健泓 |
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| 作者单位： | 广东药学院药理教研室，广东省医药学校 |
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| 摘 要： | 研究茶多酚对细胞膜脂质过氧化损伤的作用。方法采用３种自由基生成体系诱导红细胞膜脂质过氧化，脂质过氧化物用硫代巴比妥酸比色法测定。结果茶多酚对黄嘌呤－黄嘌呤氧化酶系统、Ｈ２Ｏ２及ＵＶ照射三种方法引起的细胞膜硫代巴比妥酸反应物（ＴＢＡＲＳ）生成增加均有抑制作用，其作用呈剂量依赖性，ＩＣ５０分别为２．２９、１．６５和２．７３ｍｍｏｌＬ－１。结论茶多酚对自由基引起的细胞膜脂质过氧化损伤有保护作用。
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| 关 键 词： | 茶多酚 自由基 红细胞膜 脂质过氧化 |
Protection of Tea Polyphenol against Lipid Peroxidative Damage of Erythrocyte Membrane |
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| ChEN XiaoxiaHE BingZHANG Jianhong.Protection of Tea Polyphenol against Lipid Peroxidative Damage of Erythrocyte Membrane[J].Chinese Journal of Basic Medicine In Traditional Chinese Medicine,1999,5(8):28-31. |
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| Authors: | ChEN XiaoxiaHE BingZHANG Jianhong |
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| Institution: | ChEN Xiaoxia1HE BingZHANG Jianhong2 |
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| Abstract: | Objective: To investigate the effects of Tea Polyphenol on lipid peroxidation damage of erythrocyte membrane induced by radicals.METHODS: The lipid peroxidation of erythrocyte membrane induced by radicals derrived from threee radicals generation systems models was measured by thiobarbituric acid spectrophotmetry. RESULTS: Tea Polyphenol doesdependently inhibited the increases of thiobabituric acid reactve substance (TBARS) content in the membrane exposed to xanthinexanthine oxidase system,H2O2 or UV light.The IC50 were 229,165 and 2.73 mmolL-1,respectively.HZCONCLUSION: Tea Polyphenol may protect erythrocyte membrane from the lipid peroxidative damage induced by radicals. |
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| Keywords: | Tea PolyphenolRadicalErythrocyte MembraneLipid peroxidation |
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