| 黄芪注射液对脓毒症大鼠急性肾损伤的保护作用 |
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| 引用本文： | 沈建明,沈蕾,田少江,王黎萍,李骏峰.黄芪注射液对脓毒症大鼠急性肾损伤的保护作用[J].重庆医学,2011,40(16):1619-1621. |
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| 作者姓名： | 沈建明 沈蕾 田少江 王黎萍 李骏峰 |
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| 作者单位： | 沈建明,田少江,王黎萍,李骏峰,Shen Jianming,Tian Shaojiang,Wang Liping,Li Junfeng(湖北医药学院附属人民医院肾内科,湖北十堰,442000);沈蕾,Shen Lei(复旦大学附属华山医院ICU,上海,200040) |
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| 摘 要： | 目的 探讨黄芪注射液对脓毒症大鼠急性肾损伤(AKI)的作用并探讨其机制.方法 将72只SD(Sprague Dawley)雄性大鼠随机分为假手术组、模型组和黄芪组,每组大鼠24只.采用盲肠结扎穿孔法建立大鼠脓毒症AKI模型,黄芪组术后予以黄芪注射液干预.各组在术后8、24 h各取12只大鼠,检测血清胱抑素C(Cys C...
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| 关 键 词： | 黄芪 脓毒症 急性肾损伤 肿瘤坏死因子-α 白介素-1β 核因子-κB |
Protective effects of astragalus injection on acute kidney injury induced by sepsis in rats |
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| Shen Jianming,Shen Lei,Tian Shaojiang,Wang Liping,Li Junfeng.Protective effects of astragalus injection on acute kidney injury induced by sepsis in rats[J].Chongqing Medical Journal,2011,40(16):1619-1621. |
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| Authors: | Shen Jianming Shen Lei Tian Shaojiang Wang Liping Li Junfeng |
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| Institution: | 1(1.Department of Nephrology,People′s Hospital Affiliated to Hubei University of Medicine,Shiyan,Hubei 442000,China;2.Intensive Care Unit,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China) |
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| Abstract: | Objective To explore the protective effect of astragalus injection on acute kidney injury(AKI) induced by sepsis in rats and its mechanism.Methods 72 male SD(Sprague Dawley) rats were randomly divided into sham operation group,model group and astragalus group with 24 in each group.AKI models of rat induced by sepsis were established by cecum ligation and perforation.Rats in astragalus group were treated with astragalus injection after operation.Detection of serum concerntration of Cystatin-C(Cys C),level of... |
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| Keywords: | astragalus gummifer spesis acute kidney injury tumor necrosis factor-alpha interleuklin-1belta nuclear factor-κappa B |
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