冠心苏合丸系列组方的比较药理学研究

目的：研究冠心苏合丸系列组方对急性心肌梗死和疼痛的治疗作用。方法：冠状动脉结扎法制作心肌梗死模型,通过心肌梗死面积的定量组织学测定和血栓素（TXB2）、内皮素（ET）、6-酮-前列腺素（6-keto-PGF_1α<1i>）检查、评价冠心苏合丸系列组方治疗心肌梗死的作用；腹腔注射醋酸法制作小鼠疼痛模型,观察小鼠扭体次数和潜伏期,评价其止痛作用。结果：含青木香的冠心苏合丸、含土木香的冠心苏合丸和不含青、土木香的冠心苏合丸显著减小大鼠心肌梗死范围,降低TXB₂水平和ET水平；提高6-keto-PGF_1α水平和6-keto-PGF_1α/ TXB₂比值,显著抑制小鼠疼痛；单方青木香和土木香有减缓疼痛的作用。结论：含青木香、含土木香的冠心苏合丸和不含青、土木香的冠心苏合丸对心肌梗死和疼痛均有显著的治疗作用,单方青木香和土木香主要作用是减缓疼痛。

Study on comparative pharmacology of series of Muskone

OBJECTIVE: To study the therapeutic effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on experimental myocardial infarct and pain in rats. METHOD: Coronary artery ligation was applied for the model of myocardial infarct. Therapeutic effects were evaluated by measuring parameters of histomorphometry, blood plasm of ET, 6- keto-PGF1alpha and TXB2. Intraperitoneal injection acetic was applied for the model of ache, the frequency and eclipse period of writhing were evaluated its effect of resisting pain. RESULT: The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all can decrease the area of myocardial infarction in rats, the level of TXB2, ET, and the frequency of writhing significantly. Also it can increase the level 6-keto-PGF1alpha, the ratio of 6-keto-PGF1alpha and TXB2. Single Radix Aristolociae or Radix Inulae only relieved pain. CONCLUSION: The Muskone including Radix Aristolociae, the Muskone including Radix Inulae and the Muskone without Radix Aucklandiae all have significant therapeutic effect on both myocardial infarction and pain, while single Radix Aristolociae or Radix Inulae only can relieve pain.