| 基于血管新生探讨活血化瘀中药对肿瘤转移的影响＊ |
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| 引用本文： | 王爱云,韦忠红,余苏云,钱程,邹伟,杨春媚,张珊,吴媛媛,李晓曼,陈文星,陆茵.基于血管新生探讨活血化瘀中药对肿瘤转移的影响＊[J].世界科学技术-中医药现代化,2019,21(9):1887-1891. |
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| 作者姓名： | 王爱云 韦忠红 余苏云 钱程 邹伟 杨春媚 张珊 吴媛媛 李晓曼 陈文星 陆茵 |
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| 作者单位： | 南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023;南京中医药大学,江苏省中医药防治肿瘤协同创新中心 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023;南京中医药大学,江苏省中医药防治肿瘤协同创新中心 南京 210023,南京中医药大学药学院,江苏省中药药效与安全性评价重点实验室 南京 210023;南京中医药大学,江苏省中医药防治肿瘤协同创新中心 南京 210023;南京中医药大学,中药品质与效能国家重点实验室（培育） 南京 210023 |
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| 摘 要： | 血瘀贯穿肿瘤发生发展的始终,而血瘀所致缺血缺氧状态是肿瘤血管新生发生的始动因素,对肿瘤发生远端转移起着至关重要的作用。活血化瘀是中医治疗肿瘤的重要法则。但关于活血化瘀中药对肿瘤转移是促进还是抑制,长期以来存在争议,引起临床医生的极大困惑,亟待解决。考虑到血瘀所致血管新生异常在肿瘤血行转移中的作用,课题组以血管新生为切入点,探讨活血化瘀中药对肿瘤转移的影响,为临床提供重要参考。
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| 关 键 词： | 血瘀证 血管新生 活血化瘀中药 肿瘤转移 |
| 收稿时间： | 2019/8/29 0:00:00 |
| 修稿时间： | 2019/12/13 0:00:00 |
Exploring the Effect of Chinese Medicine of Activating Blood and Eliminating Stasis on Tumor Metastasis Based on Angiogenesis |
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| Wang Aiyun,Wei Zhonghong,Yu Suyun,Qian Cheng,Zou Wei,Yang Chunmei,Zhang Shan,Wu Yuanyuan,Li Xiaoman,Chen Wenxing and Lu Yin.Exploring the Effect of Chinese Medicine of Activating Blood and Eliminating Stasis on Tumor Metastasis Based on Angiogenesis[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2019,21(9):1887-1891. |
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| Authors: | Wang Aiyun Wei Zhonghong Yu Suyun Qian Cheng Zou Wei Yang Chunmei Zhang Shan Wu Yuanyuan Li Xiaoman Chen Wenxing and Lu Yin |
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| Institution: | Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China;State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China |
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| Abstract: | Blood stasis runs through the development of tumors. The ischemic and hypoxic state caused by blood stasis is the driving factor of neovascularization, which plays a vital role in the distant metastasis of tumors. Activating blood circulation to dissipate blood stasis is an important rule for Chinese medicine in the treatment of tumor. However, whether traditional Chinese medicine for promoting blood circulation and removing blood stasis promotes or inhibits tumor metastasis has long been controversial, which causes great confusion among clinicians and urgently needs to be resolved. Considering the role of abnormal neovascularization caused by blood stasis in tumor hematogenous metastasis, the research group took neovascularization as a point of entry to explore the effect of promoting blood circulation and removing blood stasis on tumor metastasis, providing an important reference for clinical practice. |
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| Keywords: | Angiogenesis blood stasis syndrome Chinese medicine of activating blood and eliminating stasis tumor metastasis |
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