二氢槲皮素的药理作用研究进展

二氢槲皮素是从植物中提取的类黄酮类化合物,在自然界中分布广泛,具有抗肿瘤(肝癌、肺癌、乳腺癌、直结肠癌、胃癌、骨癌、宫颈癌)、抗炎、抗氧化、抗纤维化、抗过敏、抗细胞凋亡和抗病毒等多种药理作用。目前对二氢槲皮素在抗氧化、抗炎、抗纤维化和抗细胞凋亡方面的研究比较完善,但缺乏抗病毒和抗肿瘤方面的药理研究总结。就近年来国内外对二氢槲皮素的药理作用(尤其是抗肿瘤活性)的相关文献进行归纳总结,以期为后续研究和进一步药用开发提供依据。

Research progress on pharmacological effects of dihydroquercetin

Dihydroquercetin is a flavonoid compound extracted from plants and is widely distributed in nature. It has many pharmacological effects such as anti-tumor (such as liver cancer, lung cancer, breast cancer, colorectal cancer, gastric cancer, bone cancer, cervical cancer), anti-inflammatory, antioxidation, antifibrosis, antiallergy, antiapoptosis and antivirus. The existing literature on dihydroquercetin in antioxidation, anti-inflammatory, antifibrosis and antiapoptosis research is relatively perfect; however, there is a lack of summary of research on antivirus and antitumor. In this paper, the pharmacological effects of dihydroquercetin are summarized at home and abroad in recent years, especially its antitumor activity, which provides a theoretical basis for further research and further medicinal development.