| Cervitec涂膜的药物释放动力学研究 |
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| 引用本文： | 苏柏华,黄桂卿,冯岩,佘林,卢友光.Cervitec涂膜的药物释放动力学研究[J].福建医科大学学报,2011,45(1):23-25. |
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| 作者姓名： | 苏柏华 黄桂卿 冯岩 佘林 卢友光 |
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| 作者单位： | 苏柏华,冯岩,佘林,卢友光,SU Bohua,FENG Yan,SHE Lin,LU Youguang(福建医科大学,附属口腔医院预防科,福州,350002);黄桂卿,HUANG Guiqing(福州市第二医院,口腔科,福州,350007) |
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| 摘 要： | 目的 研究Cervitec涂膜药效成分的释放动力学行为,为临床评估与合理用药提供参考.方法 体外模拟口腔唾液环境,将涂膜Cervitec凝胶剂的前磨牙置于人工唾液中,采用双波长分光光度法测定1～60 d内释放入人造唾液中的药效成分醋酸氯己定和麝香草酚的含量,计算其释放度,绘制释放曲线.结果 Cervitec涂膜对醋酸氯...
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| 关 键 词： | 复合树脂类 酸类 牙本质过敏 氯已定 麝香草酚 分光光度法 紫外线 药物释放系统 |
Study on Drug Release Kinetics of Cervitec Film-Coated Agents |
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| SU Bohua,HUANG Guiqing,FENG Yan,SHE Lin,LU Youguang.Study on Drug Release Kinetics of Cervitec Film-Coated Agents[J].Journal of Fujian Medical University,2011,45(1):23-25. |
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| Authors: | SU Bohua HUANG Guiqing FENG Yan SHE Lin LU Youguang |
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| Institution: | SU Bohua1,HUANG Guiqing2,FENG Yan1,SHE Lin1,LU Youguang1 1.Department of Preventive Dentistry,The Affiliated Stomatological Hospital,Fujian Medical University,Fuzhou 350002,China,2.Department of Stomatology,The No.Two Hospital of Fuzhou,Fuzhou 350007 |
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| Abstract: | Objective To investigate the drug release kinetics of Cervitec for evaluating its clinical administration and therapeutic effect.Methods The mouth saliva condition was simulated in vitro and bicuspid teeth coated with Cervitec varnish were placed in the artificial saliva.The drug components,chlorhexidine acetate and thymol released from the Cervitec film,were simultaneously measured in the artificial saliva by a double-wavelength spectrophotometry for a period of 1～60 days.The drug release rate was calculated and kinetics curves were drawn.Results The release of chlorhexidine acetate and thymol from the Cervitec film coating mainly occurred in day 1～2,and the total release rate in the first 2 days was 4.4% and 18.2%,respectively.For chlorhexidine acetate,the day release rate stabilized after day 3 and the total release rate reached a ＂platform＂ after 60 days;for thymol,the day release rate stabilized after day 6 and the total release rate reached a platform after 30 days.Conclusion A single application of Cervitec film coating may produce preventive and therapeutic effects on odonthemodia for at least 30 days. |
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| Keywords: | Composite Resins Dentin Sensitivity Chlorhexidine Thymol Spectrophotometry Ultraviolet Drug Delivery Systems |
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