| 结直肠肿瘤中人乳头瘤病毒感染的基因分析 |
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| 引用本文： | 张金浩,耿建祥,吴崑岚,郭晓川,周伟,孙继花.结直肠肿瘤中人乳头瘤病毒感染的基因分析[J].医学研究生学报,2011,24(2):154-157. |
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| 作者姓名： | 张金浩 耿建祥 吴崑岚 郭晓川 周伟 孙继花 |
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| 作者单位： | 1. 南京中医药大学第三附属医院全国肛肠医疗中心,南京,210001
2. 南京中医药大学第三附属医院病理科,南京,210001 |
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| 摘 要： | 目的高危型人乳头瘤病毒(human papillomavirus,HPV)感染是宫颈癌的主要致病原因,现已发现HPV感染可诱发人类的许多恶性肿瘤。文中旨在探讨高危型HPV在结直肠肿瘤(colorectal tumor,CRT)中的感染情况以及与HPV感染的关系。方法从203例结直肠肿瘤石蜡组织标本中提取16、18型HPV的基因,其中结直肠绒毛-管状腺瘤(colorectal villus-tubiform adenoma,CRVTAN)83例、结直肠腺癌(colorectal adenocarcinoma,CRAC)120例,采用聚合酶链反应进行基因扩增检测,并对其患者进行临床病理资料分析。结果 83例CRVTAN总的HPV感染率为57.83%(48/83)、120例CRAC总的HPV感染率为75.00%(90/120),且与HPV感染密切相关(r分别为23.4、47.3,P<0.01)。结论结直肠肿瘤与HPV感染有着密切的关系,无论腺瘤、还是腺癌,直肠及乙状结肠都是结直肠HPV的高感染部位,这合理的解释了长期以来直肠、乙状结肠腺癌在CRAC中的高发病率现象。
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| 关 键 词： | 结直肠肿瘤 人乳头瘤病毒 聚合酶链反应 感染率 |
DNA analysis of human papillomavirus infection in patients with colorectal tumor |
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| ZHANG Jin-hao,GENG Jian-xiang,WU Kun-lan,GUO Xiao-chuan,ZHOU Wei,SUN Ji-hua.DNA analysis of human papillomavirus infection in patients with colorectal tumor[J].Bulletin of Medical Postgraduate,2011,24(2):154-157. |
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| Authors: | ZHANG Jin-hao GENG Jian-xiang WU Kun-lan GUO Xiao-chuan ZHOU Wei SUN Ji-hua |
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| Institution: | ZHANG Jin-hao1,GENG Jian-xiang2,WU Kun-lan1,GUO Xiao-chuan2,ZHOU Wei2,SUN Ji-hua2(1.National Center for Colorectal Disease Treatment,2.Department of Pathology,The Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210001,Jiangsu,China) |
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| Abstract: | Objective High-risk human papillomavirus(HPV) infection is the major cause of cervical cancer,and it has proved that HPV infection may induce various malignant tumors in human.We studied HPV infection among colorectal tumor patients and the relationship of colorectal tumors with HPV infection.Methods Types 16 and 18 HPV were obtained from the paraffin specimens of 203 cases of colorectal tumor,including 83 cases of colorectal villus-tubiform adenoma(CRVTAN) and 120 cases of colorectal adenocarcinoma(CRAC).G... |
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| Keywords: | Colorectal tumor Human papillomavirus Polymerase chain reaction Infection rate |
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