| 氨基胍对大鼠脑缺血再灌注损伤及血脑屏障的影响 |
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| 引用本文： | 王文安,王根发,周永炜,程洁.氨基胍对大鼠脑缺血再灌注损伤及血脑屏障的影响[J].上海交通大学学报(医学版),2006,26(7):755-757. |
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| 作者姓名： | 王文安 王根发 周永炜 程洁 |
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| 作者单位： | 上海交通大学医学院新华医院神经内科 上海200092 |
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| 摘 要： | 目的探讨氨基胍(AG)对大鼠脑缺血再灌注后的血脑屏障的影响及对再灌注损伤的保护作用。方法采用线栓法建立鼠大脑中动脉局灶缺血再灌注模型。于缺血2 h再灌注22 h,测定脑梗死体积,并用伊文思蓝染色荧光显微镜观察血脑屏障破坏的程度,HE染色观察中性粒细胞浸润变化。结果再灌注22 h后,AG治疗组脑梗死体积减小,脑缺血区血脑屏障破坏程度和中性粒细胞浸润程度明显减轻(P<0.05)。结论AG对脑缺血再灌注具有确切的脑保护作用,并能减轻脑缺血再灌注对血脑屏障的破坏程度和炎症细胞浸润程度。
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| 关 键 词： | 脑缺血 再灌注损伤 氨基胍 血脑屏障 |
| 文章编号： | 0258-5898(2006)07-0755-03 |
| 收稿时间： | 2006-01-03 |
| 修稿时间： | 2006年1月3日 |
Effects of Aminoguanidine on Blood Brain Barrier and Brain Ischemic Damage during Reperfusion of Cerebral Ischemia in Rats |
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| WANG Wen-an,WANG Geng-fa,ZHOU Yong-wei,CHENG Jie.Effects of Aminoguanidine on Blood Brain Barrier and Brain Ischemic Damage during Reperfusion of Cerebral Ischemia in Rats[J].Journal of Shanghai Jiaotong University:Medical Science,2006,26(7):755-757. |
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| Authors: | WANG Wen-an WANG Geng-fa ZHOU Yong-wei CHENG Jie |
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| Institution: | Department of Neurology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China |
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| Abstract: | Objective To evaluate the therapeutic effects of aminoguanidine(AG) on cerebral ischemia-reperfusion damage in rats. Methods The intravascular thread models with 2 h of occlusion and 22 h of reperfusion were made in the rats.The brain infarction size and the degree of blood brain barrier(BBB) disruption in the ischemic regions were evaluated by staining with 2,3,5-triphenyl tetrazolium chloride and observing with Evans blue fluorescence microscope.HE staining was utilized for observing neutrophil infiltration. Results The brain infarction(volume,) the area of BBB disruption and the degree of neutrophil infiltration were dramatically decreased in the treatment group as compared to the control group(P<0.05). Conclusion AG has definite protective effect on cerebral ischemia-reperfusion injury.It can also attenuate BBB disruption and neutrophil infiltration. |
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| Keywords: | cerebral ischemia damage reperfusion damage aminoguanidine blood brain barrier |
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