| 丹参抗大鼠乙酸性十二指肠溃疡作用机制的探讨 |
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| 引用本文： | 王国中,金丽,张翠香.丹参抗大鼠乙酸性十二指肠溃疡作用机制的探讨[J].现代医学,2004,32(1):14-15. |
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| 作者姓名： | 王国中 金丽 张翠香 |
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| 作者单位： | 齐齐哈尔医学院,病理生理学教研室,黑龙江,齐齐哈尔,161042 |
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| 基金项目： | 齐齐哈尔医学院科研启动资金支持项目 |
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| 摘 要： | 目的 探讨丹参抗大鼠乙酸性十二指肠溃疡的作用及机制。方法 按Okabe方法复制大鼠乙酸十二指肠溃疡模型 ,按传统方法测定溃疡指数、溃疡抑制率 ;用放射免疫法测定十二指肠溃疡部位的前列腺环素 (PGI2 )含量。结果 丹参组的溃疡指数显著低于对照组 (P <0 .0 1) ,其溃疡抑制率高于对照组 ,PGI2 的含量亦显著高于对照组 (P <0 .0 1)。结论 丹参具有抗大鼠十二指肠溃疡的作用 ,其机制可能是丹参提高了十二指肠粘膜的防御能力
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| 关 键 词： | 丹参 十二指肠溃疡 前列腺环素 作用机制 |
| 文章编号： | 1671-7562(2004)01-0014-02 |
| 修稿时间： | 2003年6月27日 |
Effect of Danshen on acetic acid-induced duodenal ulcer in rats |
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| WANG Guo-zhong,JIN Li,ZHANG Cui-xiang.Effect of Danshen on acetic acid-induced duodenal ulcer in rats[J].Modern Medical JOurnal,2004,32(1):14-15. |
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| Authors: | WANG Guo-zhong JIN Li ZHANG Cui-xiang |
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| Abstract: | ObjectiveTo explore the effect and its mechanism of Danshen on aceti c acid-induced duodenal ulcer in rats.Methods The model of acid-induced duodenal ulcer was copied in rats according to method of Okabe.The ulcer index and the inhibiting rate was d etermined according to traditional method.The content of PGI 2 at duoden al ulcer region was determined by radioimmunoassay.ResultsThe ulcer index of danshen group was remarkably lower than that of control g roup ( P <0.01),but its ulcer inhibiting rate was higher than control group, and the content of PGI 2 was remarkably higher than that of control group too( P <0.01).Conclusion Danshen have the effect on resisting acetic acid-induced duodena l ulcer in rats,the mechanism of is possibly that Danshen can advance the defense ability of duodenal mucous membrane. |
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| Keywords: | Danshen duodenal ulcer prostacycli n (PGI 2) |
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