SLP-2在胃癌中的表达及临床意义的Meta分析

目的 系统评价SLP-2在胃癌中的表达及其与临床病理参数的相关性。方法 计算机检索PubMed、Cochrane Library、EMbase、CBM、CNKI、WanFang Date和VIP数据库,检索国内外关于SLP-2在胃癌中表达的病例-对照研究,检索时限为从建库至2021年11月。由2名研究者独立检索筛选文献、提取资料并评价偏倚风险,用Revman5.3软件进行meta分析。结果 最终纳入8个病例-对照研究,共计1 079例患者。Meta分析结果显示:SLP-2在胃癌组织中的表达水平明显高于癌旁组织,差异有统计学意义OR=6.20, 95%CI(4.41, 8.73), P<0.01];胃癌组织中SLP-2在不同分化程度组OR=1.41, 95%CI(1.04, 1.93), P=0.03]、不同浸润深度组OR=3.84, 95%CI(2.70, 5.47), P<0.01]、不同淋巴结转移组OR=2.21, 95%CI(1.37, 3.56), P=0.001]、不同血行转移组OR=2.05, 95%CI(1.25, 3.35), P=0.004]、不同临床分期组OR=2.79, 95%CI(2.08, 3.74), P<0.01]中的表达水平差异均有统计学意义。结论 SLP-2在胃癌组织和癌旁组织中差异表达,在胃癌组织中的表达水平和临床病理参数相关,提示SLP-2在胃癌的发生中起作用。受到纳入文献数量与质量的限制,上述结果需要更多高质量的研究加以验证。

Expression and clinical significance of SLP-2 in gastric cancer: A meta-analysis

Objective To evaluate the correlation of the expression and pathology parameters of SLP-2 in gastric cancer.Methods Two researchers independently collected and screened case-control studies regarding SLP-2 expression in gastric cancer in domestic and foreign databases as PubMed, Cochrane Library, EMbase, CBM, CNKI, WanFang Date and VIP databases, the construction time was until November 2021; they assessed the risk of bias for these data and used Revman5.3 software for a meta-analysis.Results Eligible 8 case-control studies were included, with a total of 1079 patients. Meta-analysis showed that the expression level of SLP-2 in gastric cancer tissues was significantly higher than that in adjacent tissues OR=6.20,95%CI(4.41,8.73),P<0.01]. In gastric cancer tissues, the expression level of SLP-2 in groups with different degrees of differentiation OR=1.41,95%CI(1.04,1.93),P=0.03], groups with different depth of invasion OR=3.84,95%CI(2.70,5.47),P<0.01] and groups with different lymph node Metastasis OR=2.21,95%CI(1.37,3.56),P=0.001], groups with different blood Metastasis OR=2.05,95%CI(1.25,3.35),P=0.004], groups with different clinical stage OR=2.79,95%CI(2.08,3.74),P<0.01] was found had statistical significance. Conclusion There are significant difference in SlP-2 expression between gastric cancer tissues and adjacent tissues, which is correlated with clinicopathological parameters, suggesting that SLP-2 plays a role in gastric cancer incidence. Due to the limited quantity and quality of the above literatures, the conclusions should be verified by more high-quality studies.