广东省健康人群手足口病病原隐性感染状况调查

目的 了解广东省健康人群手足口病病原隐性感染情况.方法 在广东省7个市随机抽取7个年龄组健康儿童及成年人,采集粪便标本进行手足口病病原检测.结果 7个市共采集1285份样本,肠道病毒71型(EV71)阳性率为0.39％(5/1285),柯萨奇病毒A组16(CA16)阳性率为0.23％(3/1285),其他肠道病毒阳性率为7.00％ (90/1285).4～6岁年龄组EV71阳性率最高,为1.79％ (4/223),其次为0～3岁年龄组,为0.67％(1/223),其余年龄组均未检出EV71;只有4～6岁年龄组检出CA16,阳性率为1.35％ (3/223).所有EV71阳性标本均在本地户籍人群中检出,阳性率为0.47％(5/1063);CA16在本地户籍人群(0.19％)和外地户籍(0.85％)中均有检出,差异无统计学意义(P＞0.05).农村和城市EV71的阳性率分别为0.36％和0.54％,差异无统计学意义(P＞0.05);所有CA16阳性标本均在城市儿童中检出.结论 广东省健康人群中仅6岁以下年龄组检出EV71和CA16阳性,健康成年人中未检出EV71和CA16阳性,应重点对儿童尤其是学龄前儿童采取有效防控措施.

Survey on the recessive infection of pathogen to hand-foot-mouth disease among healthy adults and children in Guangdong province

Objective To understand the pathogen-carrying status of hand-foot-mouth disease(HFMD) among healthy people in Guangdong province. Methods Stool specimens were collected randomly on 7 age groups from 7 cities in Guangdong province. Real-time RT-PCR was used to detect enterovirus(EV), enterovirus 71(EV71) and coxsackie virus A16(CA16). Results Altogether, 1285 stool specimens were collected. The positive rates of EV71, CA16 and other enterovirus were 0.39%(5/1285), 0.23%(3/1285) and 7.00%(90/1285), respectively. The highest EV71 positive rate(1.79%) was among the 4-6-year-old group, followed by the age group 0-3 with positive rate as 0.67%. EV71 was not found among the rest age groups. The highest CA16 positive rate(1.35%) was among the 4-6 year-olds group, but the CA16 was not found among the rest age groups. EV71 was only found among native population, with the positive-rate as 0.47%. CA16-positive rate was 0.19% among the native population and 0.85% among floating population, with no significant difference found(P>0.05). The EV71 positive rate was 0.36% among rural residents and 0.54% among urban residents, but with no significant difference(P>0.05). All CA16 was found among the urban residents. Conclusion Recessive infection of EV71 and CA16 were only found among 0-6 year-old group but not found among other groups, which suggested that the approaches on prevention and control should be targeted to all children especially on pre-school children.