全文获取类型
收费全文 | 642篇 |
免费 | 78篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 6篇 |
妇产科学 | 5篇 |
基础医学 | 67篇 |
口腔科学 | 3篇 |
临床医学 | 54篇 |
内科学 | 130篇 |
皮肤病学 | 8篇 |
神经病学 | 49篇 |
特种医学 | 5篇 |
外科学 | 33篇 |
综合类 | 104篇 |
预防医学 | 132篇 |
眼科学 | 2篇 |
药学 | 72篇 |
中国医学 | 69篇 |
肿瘤学 | 34篇 |
出版年
2023年 | 20篇 |
2022年 | 43篇 |
2021年 | 44篇 |
2020年 | 51篇 |
2019年 | 27篇 |
2018年 | 24篇 |
2017年 | 25篇 |
2016年 | 35篇 |
2015年 | 35篇 |
2014年 | 72篇 |
2013年 | 71篇 |
2012年 | 58篇 |
2011年 | 58篇 |
2010年 | 40篇 |
2009年 | 34篇 |
2008年 | 28篇 |
2007年 | 30篇 |
2006年 | 13篇 |
2005年 | 6篇 |
2004年 | 12篇 |
2003年 | 6篇 |
2002年 | 4篇 |
2001年 | 6篇 |
2000年 | 3篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1987年 | 2篇 |
1984年 | 1篇 |
1982年 | 3篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
排序方式: 共有776条查询结果,搜索用时 15 毫秒
1.
《Saudi Pharmaceutical Journal》2022,30(11):1572-1588
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of a metabolic syndrome caused by excessive accumulation of fat in the liver. Orthosiphon stamineus also known as Orthosiphon aristatus is a medicinal plant with possible potential beneficial effects on various metabolic disorders. This study aims to investigate the in vitro inhibitory effects of O. stamineus on hepatic fat accumulation and to further use the computational systems pharmacology approach to identify the pharmacokinetic properties of the bioactive compounds of O. stamineus and to predict their molecular mechanisms against NAFLD. Methods: The effects of an ethanolic extract of O. stamineus leaves on cytotoxicity, fat accumulation and antioxidant activity were assessed using HepG2 cells. The bioactive compounds of O. stamineus were identified using LC/MS and two bioinformatics databases, namely the Traditional Chinese Medicine Integrated Database (TCMID) and the Bioinformatics Analysis Tool for the Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Pathway enrichment analysis was performed on the predicted targets of the bioactive compounds to provide a systematic overview of the molecular mechanism of action, while molecular docking was used to validate the predicted targets. Results: A total of 27 bioactive compounds corresponding to 50 potential NAFLD-related targets were identified. O. stamineus exerts its anti-NAFLD effects by modulating a variety of cellular processes, including oxidative stress, mitochondrial β-oxidation, inflammatory signalling pathways, insulin signalling, and fatty acid homeostasis pathways. O. stamineus is significantly targeting many oxidative stress regulators, including JNK, mammalian target of rapamycin (mTOR), NFKB1, PPAR, and AKT1. Molecular docking analysis confirmed the expected high affinity for the potential targets, while the in vitro assay indicates the ability of O. stamineus to inhibit hepatic fat accumulation. Conclusion: Using the computational systems pharmacology approach, the potentially beneficial effect of O. stamineus in NAFLD was indicated through the combination of multiple compounds, multiple targets, and multicellular components. 相似文献
2.
3.
The voltage-sensitive dye diO-C2-5 was used to produce an in vivo map of the membrane potential in two types of seizures. Mild limbic seizures were induced in rats with kainic acid; clonic convulsive seizures were induced with bicuculline. Kainic acid animals showed various levels of neural depolarization during their seizures in limbic, thalamic, cortical, and brainstem sites. The bicuculline animals showed uniformly greater levels of neural depolarization during their seizures. The magnitude of these changes relative to controls varied across seizure models and reflected the different underlying neural mechanisms for each model. The ability of the technique to capture local electrical events provides a new tool in which to explore brain activity. 相似文献
4.
5.
郭亚腾朱珠李哲明王毓佳胡坚赵永根李红霞 《中国卫生质量管理》2022,(12):019-22
川崎病遗留冠状动脉损害长期存在,需要对患儿进行长期监测。借助医院信息系统,设计了川崎病门诊临床路径管理系统。系统具备路径设置、医生工作站路径、科研统计分析、患者预约提醒等功能,可满足川崎病临床治疗和科研需求。但系统使用率、系统操作的精细化水平等有待进一步提升,可从系统支持、临床管理两方面持续改进。 相似文献
6.
7.
《Acta oto-laryngologica》2012,132(4):477-480
Objective--Patients with superior canal dehiscence (SCD) syndrome experience vertigo and oscillopsia with loud sounds and/or stimuli that result in changes in middle ear or intracranial pressure. Findings on temporal bone CT were analyzed to determine if a developmental abnormality is associated with the syndrome. Material and methods--Temporal bone CT scans [0.5 mm collimation and projections into the superior semicircular canal (SC) plane] were used to compare the bone overlying the SC in patients with SCD syndrome (20 unilateral, 7 bilateral) and in 88 patients without SCD syndrome who had undergone temporal bone CT for evaluation of other otologic disorders (controls). Results--The thickness of bone overlying the SC in the controls measured 0.67±0.38 mm (mean±SD). For individual control subjects, the thickness of bone on one side was correlated with that on the other side (r=0.43; p&;lt;0.0001). The thickness of bone overlying the SC on the intact side in patients with unilateral dehiscence measured 0.31±0.23 mm, and was thinner than that noted in the controls (p&;lt;0.0001). Conclusions--These findings support the notion that there is a developmental abnormality underlying SCD syndrome. When dehiscence is found on one side, the contralateral side is likely to be thin. 相似文献
8.
Avinoam Shuper Liora Kornreich Shalom Michowitz Michael Schwartz Isaac Yaniv Ian J. Cohen 《Pediatric hematology and oncology》2013,30(6):463-468
The authors evaluated the impact of hydrocephalus on the clinical picture of children with visua pathway tumor (VPT) with or without neurofibromatosis (NF).Charts of children with VPT treated in the authors' center since 1985 were retrospectively reviewed, and those with hydrocephalus were selected and summarized. Thirty-five children with VPT were found, of whom 20 had NF.Hydrocephalus was found in 4 children with NF (20% ) and in 5 without NF (33.3% ). In 6 ofthechildren, ventricular dilatation with signs of acute increased intracranial pressure already existed at the time of diagnosis and the hydrocephalus was shunted at this time. In the other 3 children, all with NF,the hydrocephalus resulted from slowly developing aqueductal stenosis, leading in 2 to severe visual acuity deterioration. The results suggest that in children with VPT and NF, hydrocephalus, and especially hydrocephalus resulting from aqueductal stenosis, is more frequent than in the general population of NF patients, and less frequent than in VPT patients without NF. The possibility of the indolent development of hydrocephalus should be borne in mind while following children with NF. The optic nerve, when already involved with a glioma, is more vulnerable to increased pressure. Thus, in children with VPT and NF, any ventricular dilatation should lead to a consideration of early shunting. 相似文献
9.
2型糖尿病的临床路径管理工作在北华大学附属医院已开展1年多,目前已处于稳步发展阶段,本文详细分析和细化本院2013年上半年2型糖尿病的临床路径管理工作的实施现状及实施效果,较具体的介绍了本院内分泌专科完善和实施2型糖尿病临床路径管理的实施计划,旨在推广经验,从而推动本院临床路径管理工作运行水平。 相似文献
10.
《Drug metabolism and pharmacokinetics》2019,34(5):340-349
The present study aims is to investigate the metabolic mechanism of Xue-Fu-Zhu-Yu decoction (XFZYD) in the treatment of blood-stasis syndrome in Coronary Heart Disease (CHD). To that end, 30 CHD patients with Blood-Stasis Syndrome (BSS) and 20 healthy subjects were enrolled. LC-Q-TOF/MS analysis determined that in comparison between CHD with BSS patients (Group A) and healthy subjects (Group C), 59 significantly differential metabolites in the positive mode and 18 significantly differential metabolites in the negative mode. The metabolite constituents in the plasma of 30 CHD with BSS patients before (group A) and after 30 days of treatment (Group B), and 20 healthy subjects (Group C) were analyzed using LC-Q-TOF/MS and GC-MS. Based on multivariate statistical analysis (PCA, PLS-DA and OPLS-DA), we determined 69 differential metabolites. The levels of hemorheology indexes were significantly down-regulated after treatment. Metabolic pathway attribution analysis showed that lipid metabolism, amino acid metabolism and bile acid metabolism pathways are involved. Our study identifies the metabolic networks of CHD and demonstrates the efficacy of this metabolomics approach to systematically study the therapeutic effect of XFZYC on CHD. 相似文献