全文获取类型
收费全文 | 416篇 |
免费 | 17篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 56篇 |
妇产科学 | 4篇 |
基础医学 | 25篇 |
口腔科学 | 21篇 |
临床医学 | 31篇 |
内科学 | 95篇 |
皮肤病学 | 1篇 |
神经病学 | 4篇 |
特种医学 | 6篇 |
外科学 | 65篇 |
综合类 | 67篇 |
预防医学 | 35篇 |
眼科学 | 1篇 |
药学 | 19篇 |
中国医学 | 5篇 |
肿瘤学 | 1篇 |
出版年
2022年 | 3篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 8篇 |
2017年 | 2篇 |
2016年 | 23篇 |
2015年 | 33篇 |
2014年 | 43篇 |
2013年 | 40篇 |
2012年 | 33篇 |
2011年 | 44篇 |
2010年 | 29篇 |
2009年 | 18篇 |
2008年 | 18篇 |
2007年 | 19篇 |
2006年 | 11篇 |
2005年 | 13篇 |
2004年 | 12篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 7篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 8篇 |
1995年 | 4篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 5篇 |
1981年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 2篇 |
1972年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有438条查询结果,搜索用时 78 毫秒
1.
《Vaccine》2022,40(6):904-911
BackgroundGSK initiated a Pregnancy Registry in the United States (US) for the reduced-antigen-content tetanus-diphtheria-acellular pertussis (Tdap; Boostrix, GSK) vaccine with the aim to detect and describe pregnancy outcomes in women vaccinated with Boostrix 28 days before estimated conception or during pregnancy.MethodsVoluntary reports of pregnancy exposure to Boostrix received from spontaneous and post-marketing surveillance sources in the US were assessed. Reports were classified as prospective or retrospective based on the knowledge of pregnancy outcomes at the time of reporting. For completeness, reports of exposure to Boostrix or to the Tdap-inactivated poliovirus vaccine (Boostrix-IPV, GSK) reported to the global safety database from countries outside the US were also evaluated.ResultsFrom May 2005 to August 2019, 1517 (1455 prospective and 62 retrospective) pregnancy reports were received in the Boostrix US Pregnancy Registry. Of the prospective reports, 250 had known outcomes: 244 live infants with no apparent birth defects (BDs), three live infants with BDs, and three spontaneous abortions with no apparent BDs. Of the retrospective reports, 55 had known outcomes: 33 live infants with no apparent BDs, 16 live infants with BDs, one spontaneous abortion with no apparent BDs, four stillbirths with no apparent BDs, and one stillbirth with BDs. Cumulatively, 1321 pregnancy reports (1006 for Boostrix; 315 for Boostrix-IPV) were received from countries outside the US. Of these, 163 prospective reports and 551 retrospective reports had known outcomes. Results were in line with those from the Boostrix US Pregnancy Registry.ConclusionsData currently available from the Boostrix US Pregnancy Registry and from countries outside the US suggested that exposure to Boostrix or Boostrix-IPV during pregnancy does not raise safety concerns related to adverse pregnancy outcomes or BDs. 相似文献
2.
Paulo Ernando Ferraz Cavalcanti Michel Pompeu Barros de Oliveira Sá Cecília Andrade dos Santos Isaac Melo Esmeraldo Mariana Leal Chaves Ricardo Felipe de Albuquerque Lins Ricardo de Carvalho Lima 《Brazilian Journal Of Cardiovascular Surgery》2015,30(2):148-158
Objective
To determine whether stratification of complexity models in congenital heart surgery (RACHS-1, Aristotle basic score and STS-EACTS mortality score) fit to our center and determine the best method of discriminating hospital mortality.Methods
Surgical procedures in congenital heart diseases in patients under 18 years of age were allocated to the categories proposed by the stratification of complexity methods currently available. The outcome hospital mortality was calculated for each category from the three models. Statistical analysis was performed to verify whether the categories presented different mortalities. The discriminatory ability of the models was determined by calculating the area under the ROC curve and a comparison between the curves of the three models was performed.Results
360 patients were allocated according to the three methods. There was a statistically significant difference between the mortality categories: RACHS-1 (1) - 1.3%, (2) - 11.4%, (3)-27.3%, (4) - 50 %, (P<0.001); Aristotle basic score (1) - 1.1%, (2) - 12.2%, (3) - 34%, (4) - 64.7%, (P<0.001); and STS-EACTS mortality score (1) - 5.5 %, (2) - 13.6%, (3) - 18.7%, (4) - 35.8%, (P<0.001). The three models had similar accuracy by calculating the area under the ROC curve: RACHS-1- 0.738; STS-EACTS-0.739; Aristotle- 0.766.Conclusion
The three models of stratification of complexity currently available in the literature are useful with different mortalities between the proposed categories with similar discriminatory capacity for hospital mortality. 相似文献3.
Marcelo Felipe Kozak Ana Carolina Leiroz Ferreira Botelho Maisano Kozak Carlos Henrique De Marchi Moacyr Fernandes de Godoy Ulisses Alexandre Croti Airton Camacho Moscardini 《Brazilian Journal Of Cardiovascular Surgery》2015,30(2):198-204
Introduction
Left atrioventricular valve regurgitation is the most concerning residual lesion after surgical correction of atrioventricular septal defect.Objective
To determine factors associated with moderate or greater left atrioventricular valve regurgitation within 30 days of surgical repair of incomplete atrioventricular septal defect.Methods
We assessed the results of 51 consecutive patients 14 years-old and younger presenting with incomplete atrioventricular septal defect that were operated on at our practice between 2002 and 2010. The following variables were considered: age, weight, absence of Down syndrome, grade of preoperative left atrioventricular valve regurgitation, abnormalities on the left atrioventricular valve and the use of annuloplasty. The median age was 4.1 years; the median weight was 13.4 Kg; 37.2% had Down syndrome. At the time of preoperative evaluation, there were 23 cases with moderate or greater left atrioventricular valve regurgitation (45.1%). Abnormalities on the left atrioventricular valve were found in 17.6%; annuloplasty was performed in 21.6%.Results
At the time of postoperative evaluation, there were 12 cases with moderate or greater left atrioventricular valve regurgitation (23.5%). The variation between pre- and postoperative grades of left atrioventricular valve regurgitation of patients with atrioventricular valve malformation did not reach significance (P=0.26), unlike patients without such abnormalities (P=0.016). During univariate analysis, only absence of Down syndrome was statistically significant (P=0.02). However, after a multivariate analysis, none of the factors reached significance.Conclusion
None of the factors studied was determinant of a moderate or greater left atrioventricular valve regurgitation within the first 30 days of repair of incomplete atrioventricular septal defect in the sample. Patients without abnormalities on the left atrioventricular valve benefit more of the operation. 相似文献4.
5.
低温保存成骨细胞复合生物活性玻璃陶瓷修复兔下颌骨缺损 总被引:4,自引:0,他引:4
目的 观察经低温保存的兔骨膜源性成骨细胞(POBs)的生物学特征,及其与生物活性玻璃陶瓷(BGC)体外复合后修复颌骨缺损的能力。方法 将经鉴定的幼兔骨膜源性成骨细胞置入液氮罐中保存,取冻存6个月的细胞做生物学鉴定,并进行体外培养扩增,然后与BGC复合培养,植入兔下颌骨缺损处,对照组为植入单纯BGC组。术后第2、4、8、12周取材,行X线摄片及组织学检查,观察复合材料的成骨能力。结果 复苏的成骨细胞仍具有典型的成熟成骨细胞的生物学特征,与BGC复合植入体内后,能继续生长增殖并形成骨组织,能较快较好地修复骨缺损。结论 利用冻存复苏的成骨细胞进行组织工程学研究是可行的,细胞与材料复合所形成的组织工程化骨,可望在骨组织的修复与重建中得到更加广泛的应用。 相似文献
6.
7.
Marcília S. Grassi Cristina M. A. Jacob Leslie D. Kulikowski Antonio C. Pastorino Roberta L. Dutra Nana Miura Marcelo B. Jatene Stephanie P. Pegler Chong A. Kim Magda Carneiro-Sampaio 《Arquivos brasileiros de cardiologia》2014,103(5):382-390
Background
To alert for the diagnosis of the 22q11.2 deletion syndrome (22q11.2DS) in patients with congenital heart disease (CHD).Objective
To describe the main CHDs, as well as phenotypic, metabolic and immunological findings in a series of 60 patients diagnosed with 22q11.2DS.Methods
The study included 60 patients with 22q11.2DS evaluated between 2007 and 2013 (M:F=1.3, age range 14 days to 20 years and 3 months) at a pediatric reference center for primary immunodeficiencies. The diagnosis was established by detection of the 22q11.2 microdeletion using FISH (n = 18) and/or MLPA (n = 42), in association with clinical and laboratory information. Associated CHDs, progression of phenotypic facial features, hypocalcemia and immunological changes were analyzed.Results
CHDs were detected in 77% of the patients and the most frequent type was tetralogy of Fallot (38.3%). Surgical correction of CHD was performed in 34 patients. Craniofacial dysmorphisms were detected in 41 patients: elongated face (60%) and/or elongated nose (53.3%), narrow palpebral fissure (50%), dysplastic, overfolded ears (48.3%), thin lips (41.6%), elongated fingers (38.3%) and short stature (36.6%). Hypocalcemia was detected in 64.2% and decreased parathyroid hormone (PTH) level in 25.9%. Decrease in total lymphocytes, CD4 and CD8 counts were present in 40%, 53.3% and 33.3%, respectively. Hypogammaglobulinemia was detected in one patient and decreased concentrations of immunoglobulin M (IgM) in two other patients.Conclusion
Suspicion for 22q11.2DS should be raised in all patients with CHD associated with hypocalcemia and/or facial dysmorphisms, considering that many of these changes may evolve with age. The 22q11.2 microdeletion should be confirmed by molecular testing in all patients. 相似文献8.
Background:To investigate the surveillance trend of birth defects,incidence,distribution,occurrence regularity,and their relevant factors in Xi'an City in the last 10 years for proposing control measur... 相似文献
9.
10.
目的:报道经胸骨下段小切口修补房/室间隔缺损术式的应用经验。方法按以下标准分为两组:1.胸骨下段小切口组:2013年8月至2014年2月连续房/室间隔缺损患者32例,均经胸骨下段小切口在心脏停跳下修补房/室间隔缺损;2.常规开胸组:2012年2月至2014年2月近两年行常规开胸房/室缺手术113例,使用倾向性评分方法选出32例,使其年龄、体重、性别比例及缺损大小、主要手术类型与胸骨下段小切口组相仿,均行常规胸骨正中劈开切口,在心脏停跳下进行修补手术。收集相关病历资料,比较两组的手术时间、体外循环时间、术后机械通气时间、术后引流量及术后住院天数。结果胸骨下段小切口组与常规开胸组相比,切口长度、术后机械通气时间及术后24 h 引流量显著短于后者而手术时间、ICU 停留时间及术后住院天数无显著差异。结论经胸骨下段小切口修补房/室间隔缺损是一种安全、可靠、美观、恢复快且疼痛小的微创手术方法。 相似文献