排序方式: 共有37条查询结果,搜索用时 109 毫秒
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目的 合成一种具有游离伯胺的卡莫司他衍生物.方法 以对羟基苯乙酸为原料,经4步反应得到目标化合物.结果与结论 成功制备了目标产物,所得产物的化学结构经1HNMR、MS确认. 相似文献
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对新合成的四氢叶酸辅酶模型碘化1、2-一二甲基—3—对甲氧苯磺酰基咪唑啉及与亲核试剂反应生成的产物进行了~1HNMR谱的研究,通过化学位移及偶合常数研究探讨其规律性。 相似文献
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《Journal of labelled compounds & radiopharmaceuticals》2002,45(8):665-673
The title compound, 3a , when exchange labeled with 125I results in three new labeled products. The major labeled product (84.1%) is 1‐(4‐deoxy‐4‐iodo‐β‐L‐arabinopyranosyl)‐2‐nitroimidazole, 3b , that could result from inversion of configuration at C‐4. Exchange labeling carried out under conditions of kinetic control yielded dramatically different product ratios than thermodynamic equilibrium reactions. Confirmation of these results was established by extensive 1HNMR spectral analyses. A possible mechanism is presented. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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Angelica Dessì Roberta Pintus Silvia Marras Flaminia Cesare Marincola Anna De Magistris Vassilios Fanos 《Expert review of molecular diagnostics》2016,16(10):1053-1058
Introduction: Necrotizing enterocolitis (NEC) is a serious inflammation of the bowel that most often affects premature infants. The exact cause of NEC is still poorly understood but investigators believe that these different factors can play an important role: prematurity and immaturity of the intestine of the preterm newborns, differences in the intestinal bacterial colonization and an abnormal immune response. Since the early symptoms of NEC are often rather non-specific, the diagnosis of NEC can be difficult. Therefore, the search for diagnostic biomarkers for NEC remains warranted. This review focuses on the results of recent metabolomics investigations on NEC, providing important contributions to the understanding of the biochemical process characterizing this disease.
Areas covered: Only a few metabolomics applications of NEC are reported in the literature. The metabolic pathway principally altered in NEC patients is suggested to be linked to the carbohydrates metabolism and the role of gluconate as a predictive marker for this pathology is investigated.
Expert commentary: Biomarkers are crucial as a confident diagnostic tool to make NEC therapy more efficient. Although only a few metabolomics studies have been performed in NEC research, this technique proved to be helpful to understand the pathophysiological mechanisms of this disease. 相似文献
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目的:研究新的天然产物芳酯基取代单糖的波谱特征.方法:从光苞紫菊(Notoseris psilolopis Shih)中分离得到三个芳酯基取代单糖化合物,用红外光谱、质谱、核磁共振氢谱与碳谱进行测试.结果:三个新化合物的红外光谱3400 cm-1处有典型的羟基吸收,1730~1724 cm-1有典型的酯基吸收,1600~1400 cm-1有苯环的骨架吸收;质谱上应采用快原子轰击质谱(FAB)、电喷雾质谱(ESI)等软电离技术确定它们的分子量和分子式;由于互变异构体的存在,核磁共振谱有特征较明显的异头氢和异头碳信号.结论:归纳三个新的化合物的波谱特征. 相似文献
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甙中寡糖链结构测定的核磁共振研究 总被引:2,自引:0,他引:2
目的:直接测定甙类药物中寡糖链的结构。方法:新建立的一维SEMDY,旋转坐标系NOE差谱和选择性远程DEPT核磁共振技术相互配合。结果和结论:采用一维SEMDY技术可以从高度重叠的^1H-NMR谱中得到糖体的吸收形亚谱,为利用NOE与核间距关系确定糖体之间和糖体与甙元之间的连接方式创造了条件。采用旋转坐标系NOE差谱技术测定不受分子相关时间的影响,并且可以从高度重叠的^1H-NMR谱中定量测定NO 相似文献