A controlled trial with miconazole (R 14 889) in the prevention of yeast infections occurring after treatment of vaginal trichomoniasis

A study was performed to determine the effect of miconazole on the occurrence of pathogenic yeasts after metronidazole treatment in 40 patients with vaginal trichomoniasis. The patients were randomly divided into two groups of 20. Group 1 received orally 250 mg of metronidazole b.i.d. for 10 days. Group 2 applied miconazole once daily for 14 days in addition to an identical metronidazole treatment.Microbiological examinations and pH determinations were done before and after treatment. Before treatment yeasts were found in six patients of the miconazole group and in three patients of the control group; after treatment two and seven occurrences were found, respectively.A significant decrease in vaginal pH was observed in both groups after treatment. After treatment trichomonads were still found in two patients of the control group and in none of the patients in the miconazole group.On the basis of these data it may be advisable to use miconazole along with trichomonacidal treatment in patients with vaginal trichomoniasis.     

斯皮仁诺胶囊治疗肛周念珠菌病13例疗效观察

目的：观察口服斯皮仁诺胶囊(伊曲康唑)治疗肛周念珠菌病的疗效。方法：对临床上确诊的13例肛周念珠菌病患者采用口服斯皮仁诺胶囊短程间歇性冲击疗法。结果：经治疗2个疗程后，全部患者自觉症状消失，真菌客观指标均转阴。结论：斯皮仁诺胶囊治疗肛周念珠菌病复发率低，无毒副作用，为目前治疗念珠菌病的较理想药物。     

Evaluation of a dehydrated test strip, Microstix®-Candida, for detection of Candida-induced denture stomatitis

abstract – The outgrowth of yeasts from the fitting surface of the maxillary denture and the palatal mucosa was estimated in 63 denture wearers by means of smears and by culture on Microstix®-Candida (M–C). There was a significant relationship between the concentration of yeasts as assessed by smears and by M–C. There were confluent spots on M–C, indicating large numbers of yeast cells, in 81 % of 37 denture wearers with a positive microscopic diagnosis for Candida-induced denture stomatitis, whereas there were confluent spots on M–C in only one of 26 denture wearers with a negative microscopic diagnosis for infection. It is concluded that the M–C test system seems to have sufficient diagnostic sensitivity to be an alternative to the smear for establishing the diagnosis of Candida-induced denture stomatitis.     

Clinical evaluation of econazole nitrate in 1% vaginal cream for treatment of vaginal candidosis.

30 patients with mycologically confirmed vaginal candidosis on culture were treated with econazole vaginal cream (Gyno-Pevaryl) applied intravaginally once a day for 2 wk. 8 days after the end of treatment, mycological and clinical cures were demonstrated in 26 patients. Symptoms generally subsided rapidly, and the drug was well tolerated. This study confirms the efficacy of econazole in the treatment of vaginal candidosis.     

Evaluation of a topical steroid antibiotic combination (halcinonide-neomycin-amphotericin) in the treatment of cutaneous candidiasis and inflammatory dermatoses

Summary

Halcinonide-neomycin-amphotericin (HNA) cream was evaluated in the treatment of cutaneous candidiasis and inflammatory dermatoses. The anti-candidal properties of HNA were assessed in a parallel comparison with iodochlorhydroxyquin-hydro-cortisone (I-HC) as the control drug. The overall therapeutic response with HNA was excellent in 38 (95%) of 40 patients as compared to 17 (43%) of 40 treated with I-HC. In 50 patients treated for psoriasis, eczematous dermatitis, or neurodermatitis, HNA was evaluated in a paired comparison with hydrocortisone (HC). The overall therapeutic response with HNA was excellent in 36 (72%) patients as compared to 18 (36 %) with HC. There were no adverse reactions with HNA or the control drugs.     

清化肃肺汤治疗肺念珠菌病37例疗效观察

目的：探寻中医药治疗肺念珠菌病的辨证规律和临床疗效。方法：将37例肺念珠菌病患者按辨证分为痰热郁肺、痰湿蕴肺、肺阴亏虚3型，采用清热解毒、化湿祛痰、肃肺止咳为治则的清化肃肺汤加减治疗。结果：治愈9例，有效23例，无效5例，总有效率为86．5％。结论：中医辨证治疗肺念珠菌病具有满意的疗效，值得深入研究。     

儿童皮肤念珠菌病81例临床分析

为了解儿童皮肤念珠菌病的发病情况，我们对门诊患该病患儿进行了临床观察，发现该病主要发生在一岁以内的婴幼儿(占85．2％)。男性患儿略多于女性患儿，1，3：1。皮损以扁平苔藓样皮肤念珠菌病居多(占50．6％)。致病菌主要为白色念珠菌。     

356例念珠菌性阴道炎复查结果与取样时间的关系

目的探讨念珠性阴道炎不同体征和症状的发生率,以及白带取样距离末次给药时间对念珠菌性阴道炎复查结果的影响。方法门诊念珠性阴道炎复查患者中,快速革兰氏染色,镜下找到念珠菌孢子和菌丝或单找到孢子都确认为阳性。结果356例患者中,23.04%无明显症状;复查阳性率随末次给药距离白带标本取样时间的延长逐步下降,〈24h阳性率最高,为83.90%,72～96h后趋于稳定,各组间差异有显著性（P〈0.05）,〈24h时假阴性率最高（35.50%）,与其他各组差异明显（P〈0.05）。结论念珠菌性阴道炎复查阳性率随末次给药距离白带标本取样时间的延长逐步下降,停药4d后结果趋于稳定     

An epidemiologic study of yeasts in elderly denture wearers

ABSTRACT The purpose of this study has been to assess the prevalence of denture stomatitis and Candida infection in an elderly Danish population. Ten percent of the population above the age of 65 in a Danish community was selected randomly. The study group consisted of 465 persons wearing a removable maxillary denture, who were examined in their homes. Yeasts were isolated by oral swabs for cultivation and by mucosal and denture scrapings for microscopy. The prevalence of denture stomatitis was 65 %. Yeasts, especially C. albicans, were cultivated in most denture wearers with denture stomatitis (Group 1) or with clinically normal palatal mucosa (Group 2). However, large accumulations of hyphae were present in 77 % of the patients in Group 1 compared with 47 % in Group 2; both hyphae and inflammatory cells were seen in smears in 65 % of Group 1 but only in 14 % of Group 2. On the other hand, bacterial contamination of the smears was more pronounced in Group 2 than in Group I. The study has revealed that Candida infection and poor denture cleanliness are very common in elderly denture wearers.     

Bifonazole in the treatment of fungal skin infections in the tropics: a clinical and mycological study

Summary

A study was carried out in 40 patients with various superficial fungal diseases, confirmed by culture or microscopic examination, to assess the therapeutic efficacy and local tolerability of 1% bifonazole cream. Patients with more than one clinical diagnosis at the time of entry were treated according to the number of conditions present. The cream was applied once daily to the affected areas and treatment duration varied according to persistence or resolution of the clinical signs and symptoms in the individual patient. The results were evaluated by clinical and mycological examination 3 and 14 days after the end of treatment. A cure rate of 100% was achieved in cases of pityriasis versicolor, tinea corporis and candidiasis, and 90% in patients with tinea pedis. Clinical signs and symptoms disappeared completely in all but a few patients. No side-reactions were observed in any patient, and patch tests carried out in selected patients with known allergy and those with normal skin showed no evidence of any allergic or photosensitivity reaction to bifonazole.