Correction to: Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma

Journal of Neuro-Oncology -     

Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma

Journal of Neuro-Oncology - The relationship between peritumoral neuronal activity, early onset clinical seizures, and glioma survival outcomes remains poorly understood. Hyperexcitability on...     

The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response

Sensory perception requires accurate encoding of stimulus information by sensory receptor cells. We identified NCKX4, a potassium-dependent Na(+)/Ca(2+) exchanger, as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons (OSNs). Nckx4(-/-) (also known as Slc24a4) mouse OSNs displayed substantially prolonged responses and stronger adaptation. Single-cell electrophysiological analyses revealed that the majority of Na(+)-dependent Ca(2+) exchange in OSNs relevant to sensory transduction is a result of NCKX4 and that Nckx4(-/-) mouse OSNs are deficient in encoding action potentials on repeated stimulation. Olfactory-specific Nckx4(-/-) mice had lower body weights and a reduced ability to locate an odorous source. These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception.     

Characteristics of an intraoral cone for electron beam therapy with an 18 MeV linear accelerator

A 3.0 cm diameter X ray intraoral cone was attached to the end of a 4.0 cm × 4.0 cm electron beam applicator for an 18 MeV linear accelerator. The central axis depth dose, X ray contamination, field flatness, and isodose distributions were determined for this configuration at five electron beam energies with film, using ionization chamber measurements as a check on the dosimetry. These data indicated possible clinical advantages with the electron beam as compared to an X ray beam.     

Dosimetry of an endocavitory treatment system

The dosimetric properties of an x-ray applicator system for the treatment of rectal carcinoma by endocavitory contact therapy are discussed. Half-value layer, percent depth dose, field flatness, and output dose rate were evaluated. Film was used to evaluate field flatness and ionization chambers were used to evaluate the other quantities. The methods of measurement and their results are discussed.     

Carcinoma of the lip.

We reviewed 250 patients with carcinoma of the lip who were treated with radiation therapy during a 30-year period. Although radiation techniques underwent continued refinement, the radiation dose delivered to the tumor remained relatively constant. Nearly all tumors were squamous cell carcinoma (247/250) and located on the lower lip (240/250). Only 9% initially manifested lymph node metastases. The median survival was 13.8 years. Treatment failure occurred in 11% of patients. Surgery salvaged half of these patients. Eighteen patients died from carcinoma of the lip, and six others had persistent tumor when last seen. Our experience would support the work of others. Early lesions can be successfully managed by either surgical or radiation treatment. The intermediate tumors and those near the commissure are better handled by radiation. Late lesions and those with lymph node metastases challenge the best surgical and radiation techniques.