全文获取类型
收费全文 | 3834篇 |
免费 | 248篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 179篇 |
妇产科学 | 127篇 |
基础医学 | 436篇 |
口腔科学 | 50篇 |
临床医学 | 233篇 |
内科学 | 982篇 |
皮肤病学 | 89篇 |
神经病学 | 212篇 |
特种医学 | 117篇 |
外科学 | 448篇 |
综合类 | 119篇 |
预防医学 | 233篇 |
眼科学 | 240篇 |
药学 | 397篇 |
中国医学 | 25篇 |
肿瘤学 | 194篇 |
出版年
2023年 | 19篇 |
2021年 | 62篇 |
2020年 | 43篇 |
2019年 | 59篇 |
2018年 | 109篇 |
2017年 | 71篇 |
2016年 | 83篇 |
2015年 | 94篇 |
2014年 | 131篇 |
2013年 | 154篇 |
2012年 | 291篇 |
2011年 | 291篇 |
2010年 | 185篇 |
2009年 | 116篇 |
2008年 | 211篇 |
2007年 | 190篇 |
2006年 | 195篇 |
2005年 | 191篇 |
2004年 | 187篇 |
2003年 | 170篇 |
2002年 | 152篇 |
2001年 | 74篇 |
2000年 | 71篇 |
1999年 | 65篇 |
1998年 | 31篇 |
1996年 | 31篇 |
1995年 | 17篇 |
1994年 | 21篇 |
1993年 | 18篇 |
1992年 | 44篇 |
1991年 | 54篇 |
1990年 | 46篇 |
1989年 | 42篇 |
1988年 | 51篇 |
1987年 | 37篇 |
1986年 | 37篇 |
1985年 | 21篇 |
1984年 | 28篇 |
1983年 | 16篇 |
1982年 | 26篇 |
1981年 | 31篇 |
1980年 | 16篇 |
1979年 | 32篇 |
1977年 | 17篇 |
1974年 | 20篇 |
1973年 | 29篇 |
1972年 | 39篇 |
1971年 | 17篇 |
1970年 | 29篇 |
1969年 | 16篇 |
排序方式: 共有4094条查询结果,搜索用时 28 毫秒
1.
2.
Uday Yanamandra Prateek Deo Kamal Kant Sahu Ram Vasudevan Nampoothiri Nalini Gupta Anusree Prabhakaran Deb Prasad Dhibhar Alka Khadwal Gaurav Prakash Man Upadesh Singh Sachdeva Deepesh Lad Neelam Varma Subhash Varma Pankaj Malhotra 《Clinical Lymphoma, Myeloma & Leukemia》2019,19(3):183-189.e1
Background
Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. MM primarily affects bone marrow, but extramedullary sites can also be involved. Myelomatous pleural effusion (MPE) is an atypical and rare complication of MM. We aimed to systematically study the incidence and clinicopathologic profile of patients with MPE in a real-world setting.Patients and Methods
In this retrospective study, 415 consecutive patients with MM managed at a tertiary care center in North India during a study period of January 1, 2010 to December 31, 2015 were evaluated for MPE. The patients with MPE were analyzed for their clinical profile, diagnosis, treatment, and outcomes.Results
Of these 415 patients, 11 (2.65%) patients had MPE. The median age of the study population was 50 years with male preponderance. The majority of these patients had immunoglobin (Ig)G Kappa disease. All patients had higher than International Staging System stage I disease. MPE was a presenting feature at MM diagnosis in 45.45% (n = 5) of the patients, whereas the rest developed MPE during follow-up. MPE presented predominantly (81.8%) as a unilateral effusion. Concurrent extramedullary involvement at other site was seen in 45.45% (n = 5), with 3 (27%) patients having concurrent myelomatous ascites. Six of these were managed aggressively, whereas 5 patients opted for palliation. The outcomes were dismal (90.9% mortality), with a median survival of 2.47 months.Conclusion
MPE is a rare entity, and positive outcomes of therapy remain low with dismal prognosis. 相似文献3.
4.
A. Das M. Alshareef F. Henderson J. L. Martinez Santos W. A. Vandergrift S. M. Lindhorst A. K. Varma L. Infinger S. J. Patel D. Cachia 《Clinical & translational oncology》2020,22(7):1138-1145
N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in grade-III meningioma [anaplastic meningioma (AM)] and associated with clinically aggressive 相似文献
5.
Amith Subhash James L Buxbaum James H Tabibian 《World journal of gastrointestinal endoscopy》2022,14(2):63-76
Peroral cholangioscopy (POC) is an endoscopic procedure that allows direct intraductal visualization of the biliary tract. POC has emerged as a vital tool for indeterminate biliary stricture evaluation and treatment of difficult biliary stones. Over several generations of devices, POC has fulfilled additional clinical needs where other diagnostic or therapeutic modalities have been inadequate. With adverse event rates comparable to standard endoscopic retrograde cholangioscopy and unique technical attributes, the role of POC is likely to continue expand. In this frontiers article, we highlight the existing and growing clinical applications of POC as well as areas of ongoing research. 相似文献
6.
7.
8.
9.
Handling and reporting of orchidectomy specimens with testicular cancer: areas of consensus and variation among 25 experts and 225 European pathologists 下载免费PDF全文
Daniel M Berney Ferran Algaba Mahul Amin Brett Delahunt Eva Compérat Jonathan I Epstein Peter Humphrey Mohammed Idrees Antonio Lopez‐Beltran Cristina Magi‐Galluzzi Gregor Mikuz Rodolfo Montironi Esther Oliva John Srigley Victor E Reuter Kiril Trpkov Thomas M Ulbright Murali Varma Clare Verrill Robert H Young Ming Zhou Lars Egevad 《Histopathology》2015,67(3):313-324
10.
Preeti Bhoria Saniya Sharma Neelam Varma Pankaj Malhotra Subhash Varma 《Platelets》2015,26(2):119-126
The activation status of platelets in Immune Thrombocytopenia (ITP) patients – which is still somewhat controversial – is of potential interest, because activated platelets tend to aggregate (leading to excessive clotting or thromboembolic events) but cannot do so when platelet numbers are low, as in ITP. Although corticosteroids are the first line of therapy in ITP, the effect of steroids on activation of platelets has not been evaluated so far. We examined the status of platelet activation (with and without stimulation with ADP) in ITP patients, at the start of therapy (pre-steroid treatment, naive) and post-steroid treatment (classified on the basis of steroid responsiveness). We used flow cytometry to evaluate the levels of expression of P-selectin, and PAC-1 binding to platelets of 55 ITP patients and a similar number of healthy controls, treated with and without ADP. We found that platelets in ITP patients exist in an activated state. In patients who are responsive to steroids, the treatment reverses this situation. Also, the fold activation of platelets upon treatment with ADP is more in healthy controls than in ITP patients; treatment with steroids causes platelets in steroid-responsive patients to become more responsive to ADP-activation, similar to healthy controls. Thus steroids may cause changes in the ability of platelets to get activated with an agonist like ADP. Our results provide new insights into how, and why, steroid therapy helps in the treatment of ITP. 相似文献