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Walid Kamal Abdelbasset Gopal Nambi Marwa M Eid Safaa M Elkholi 《World Journal of Psychiatry》2021,11(12):1267-1273
The corona virus disease 2019 (COVID-19) pandemic has resulted in most nations deciding upon self-isolation and social distancing policies for their citizens to control the pandemic and reduce hospital admission. This review aimed at evaluating the effect of physical activity on mental well-being during the COVID-19 pandemic. It was concluded that the COVID-19 pandemic may lead to augmented levels of angiotensin-converting enzyme (ACE)-2 that led to cardiovascular and neurological disorders associated with highly inflammatory effects of viral infection affecting the brain tissues leading to damage of the nervous system and resulting in cognition dysfunction, insulin sensitivity reduction, and behavioral impairments. Anxiety and depression may lead to negative effects on various quality of life domains, such as being physically inactive. Regular physical activities may reduce inflammatory responses, improve ACE-2 responses, and improve mental well-being during self-isolation and social distancing policies related to the COVID-19 pandemic. Further studies should be conducted to assess the different intensities of physical activities on cardiova scular function, and mental well-being during the COVID-19 pandemic. 相似文献
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Shwikar AbdelSalam Ahmed Azza Mahmoud Elhefnawy Hanan Galal Azouz Yara Safwat Roshdy Mona Hamdy Ashry Ahmed Elsayed Ibrahim Marwa Ahmed Meheissen 《Journal of molecular neuroscience : MN》2020,70(6):887-896
The role of gut microbiome was recently raised in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD). The aim of this study was to elucidate changes in gut microbiome in Egyptian autistic children and its possible correlation with the severity of autism and gastrointestinal (GI) symptoms. The gut bacterial microbiome of 41 ASD children, 45 siblings, and 45 healthy controls were analyzed using quantitative SYBR Green real-time PCR technique targeting 16S rRNA of selected bacteria. The gut microbiome of ASD children and their siblings contained a higher relative abundance of Bacteroides as well as Ruminococcus than controls. Prevotella/Bacteroides (P/B) ratio and Firmicutes/Bacteroidetes (F/B) were significantly lower in both ASD cases and their siblings. The only difference between the autistic cases and their siblings was the significantly higher level of Bifidobacterium in siblings, which appears to offer them a protective role. There was no correlation between the altered gut microbiome and the severity of autism or GI symptoms. The current study showed an evidence of changes in the gut microbiome of autistic children compared to the unrelated control. However, the microbiome profile of siblings was more like that of autistic children than that of unrelated controls indicating that gut microbiota is affected by dietary habits, living conditions together with host genetic factors. 相似文献
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Marwa M.M. Refaie Rehab A. Rifaai Asmaa M.A. Bayoumi Sayed Shehata 《Fundamental & clinical pharmacology》2020,34(3):302-312
Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences and complications are very serious. So, the search for more antioxidants and anti-inflammatory agents with cardioprotective effects is an urgent task. We aimed to evaluate the effects of a heme oxygenase 1 (HO1) inducer, hemin (HEM), on isoprenaline (ISO)-induced myocardial damage. Forty-five Wistar albino rats were used. Animals were treated with HEM (25 mg/kg/day) i.p. for 5 days and injected with ISO (150 mg/kg/day) i.p. on 4th and 5th day of the experiment. Detection of the role of ATP-sensitive potassium channel (KATP) was performed by administration of glibenclamide (GP) (5 mg/kg/day) orally 2 h before HEM. Moreover, the role of endothelial nitric oxide synthase (eNOS) was detected by coadministration of Nitro- ω-L-arginine (L-NNA) (25 mg/kg/day) for 5 days. The ISO group showed increase in heart weight, cardiac enzymes, tumor necrosis factor alpha (TNFα), and malondialdehyde (MDA) with decrease in reduced glutathione (GSH), HO1, and total antioxidant capacity (TAC). In addition, there were increases in Bcl-2 associated X protein (Bax) and cleaved caspase-3, but decreases in B-cell lymphoma-2 (Bcl-2) and eNOS. Moreover, the histopathological examination of the ISO group showed degeneration of the cardiac muscle fibers and marked infiltration of the inflammatory cells. The biochemical and histopathological changes induced by ISO were markedly ameliorated in the HEM plus ISO group. This protective effect was diminished with coadministration of GP or L-NNA; thus, KATP and eNOS might mediate HEM cardioprotection. 相似文献
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Abdelhalim Nermeen Mohamed Ibrahim Marwa Mohamed 《International urology and nephrology》2020,52(3):409-415
International Urology and Nephrology - Nocturnal enuresis is an infrequent uncontrolled voiding during sleep in a child aged 5 years or more without any congenital or acquired disorders of... 相似文献
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We sought to explore the roles of the hippocampal subregions and adjacent medial temporal lobe regions in pattern separation and any differential contributions based on sequential or spatial information. Young adults performed an incidental‐encoding task on a sequence of four objects presented on the screen in one of eight locations while we collected high‐resolution functional MRI brain scans. We employed five trials of interest: first presentations, exact repetitions, lures in which the same objects were repeated in different locations (spatial lures), lures in which the same objects were presented in a different sequential order (sequential lures), and lures in which both the spatial location and sequence were changed (both lures). We found no evidence for spatial or sequential specialization in the hippocampal subfields, consistent with the hypothesis that the dentate gyrus acts as a universal pattern separator. Likewise, we did not observe specialization for the perirhinal or parahippocampal cortices for spatial or sequential information, though both regions show evidence for associative processing in this task. © 2013 Wiley Periodicals, Inc. 相似文献
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Kamal El-Gafary Wael El-adly Osama Farouk Mohamed Khaled Marwa Mahmoud Abdelaziz 《European orthopaedics and traumatology》2014,5(1):9-14