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1.
Evaluation of miRNA 223/125a and COBLL1 Expressions and ROR-1 Levels as Reliable Markers in B- chronic Lymphocytic Leukemia 下载免费PDF全文
Samia HusseinAbdallah S AbdelazemShimaa AbdelmoneemAL-Shabrawy M AbdelnabiTarek KhamisAhmed Ali ObayaHuda F Ebian 《Asian Pacific journal of cancer prevention》2022,23(8):2735-2742
Background: miRNA 223 /125a and Cordon-bleu Protein Like 1 (COBLL1) are novel biomarkers that can predict prognosis and guide treatment decisions in patients with chronic lymphocytic leukemia (CLL). Also, there is a growing interest in CLL monitoring based on flow cytometry of receptor tyrosine kinase-like orphan receptor-1 (ROR-1). Objective: This study aimed to evaluate the relationship between miRNA 223 /125a and COBLL1 expressions and ROR-1 expression in patients with CLL. Also, the study evaluated the relationship between the expression of these biomarkers with tumor staging and cancer progression. Methods: Our study included 40 patients newly diagnosed with B-CLL. In peripheral blood (PB), miRNA 223/125a and COBLL1 expressions were detected by real-time polymerase chain reaction (real-time PCR) and ROR-1 percentage was detected by flow cytometry before and after treatment. Results: High level of COBLL1 expression was statistically significantly associated with high ROR-1 percentage expression (P= 0.03). However, a high level of miRNA 223/125a expression was statistically significantly associated with low ROR-1 percentage expression (P=0.002). The sensitivity and specificity of ROR-1 as a predictor of high WBCs count after treatment were 96.6 and 81.1%, respectively. There was a statistically significant reduction of ROR-1 percentage after treatment compared to before treatment (P <0.001). Conclusion: ROR-1 percentage expression can be considered a possible prognostic predictor in CLL along with miRNA 223/125a and COBLL1 expressions. This can be explained by the significant correlation between ROR-1 and the studied molecular biomarkers; miRNA 223/125a and COBLL1. In addition, there was a significantly higher ROR-1 percentage in patients with higher WBC counts. Moreover, there was a significant reduction in ROR-1 percentage after treatment. 相似文献
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Eman Hamid MD PhD Biniyam A. Ayele MD Daniel Gams Massi MD Samia Ben Sassi MD Houyam Tibar MD Emmanuel Epenge Djonga MD Sarah Misbah El-Sadig MD Wahiba AMER EL KHEDOUD MD Julien Razafimahefa MSc Ange Eric Kouame-Assouan MD Djibrilla Ben-Adji MD Yilédoma Thierry Modeste Lengané MD Abdu Kisekka Musubire MD Muhyadin Hassan Mohamed MSc Tiwonge Elisa Phiri MBBS FCN Nsengiyumva Nestor MD Wael Abdulgader Alwahchi MSc Saara Ndinelago Neshuku MBChB FCN MMed Cassandra Ocampo MD Foksouna Sakadi MD Moulid Ali Maidal MBBS Gift Wilson Ngwende MBChB MMed FCP Juzor Hooker MB ChB MMed DCN FCP Kigocha Okeng'o MD Med MSc Augustina Charway-Felli MD PhD FGCPS Masharip Atadzhanov PhD FRCP Jonathan Carr MBChB PhD Njideka U. Okubadejo MBChB FMCP FAAN Ali Shalash MD PhD 《Movement disorders》2021,36(10):2393-2407
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Tarek K. Motawi Samy A. Abdelazim Hebatallah A. Darwish Samia A. Shouman 《Nutrition and cancer》2016,68(3):435-445
Despite tamoxifen (TAM) is beneficial in treating a significant proportion of patients with breast cancer, many women still relapse after long-term therapy. Caffeic acid phenethyl ester (CAPE) is a component of honeybee propolis, with a plethora of important biological actions including anticancer activity. This study aimed to explore the cytotoxicity, the type of drugs interaction as well as the apoptotic and autophagic pathways of the combined treatment of TAM and CAPE in MCF-7 cells. Their antitumor activity and effect on survival of mice bearing Ehrlich tumor were also analyzed. The results showed synergistic cytotoxic effects, manifested by significant activation of apoptotic machinery, along with downregulation of protein levels of Bcl-2 and beclin-1, upon using the combination regimen. However, the ratio between microtubule-associated protein light chain 3-II and -I was not altered. Moreover, a decrease in vascular endothelial growth factor level was detected. Similarly, TAM + CAPE increased the life span of tumor-bearing animals and caused a marked regression in their tumor size and weight compared with those treated with either TAM or CAPE alone. In conclusion, CAPE relatively improved the anticancer activity of TAM in both in vitro and in vivo models via its apoptotic and angiostatic potentials. 相似文献
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HEC Forum - Studies on end-of-life care reveal different practices regarding withholding and/or withdrawing life-sustaining treatments between countries and regions. Available data about... 相似文献
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An animal component free medium that promotes the growth of various animal cell lines for the production of viral vaccines 总被引:1,自引:0,他引:1
IPT-AFM is a proprietary animal component free medium that was developed for rabies virus (strain LP 2061) production in Vero cells. In the present work, we demonstrated the versatility of this medium and its ability to sustain the growth of other cell lines and different virus strains. Here, three models were presented: Vero cells/rabies virus (strain LP 2061), MRC-5 cells/measles virus (strain AIK-C) and BHK-21 cells/rabies virus (strain PV-BHK21). The cell lines were first adapted to grow in IPT-AFM, by progressive reduction of the amount of serum in the culture medium. After their adaptation, BHK-21 cells grew in suspension by forming clumps, whereas MRC-5 cells remained adherent. Then, kinetics of cell growth were studied in agitated cultures for both cell lines. In addition, kinetics of virus replication were investigated. 相似文献
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Letter: concordance of SVR4 and SVR12 following direct‐acting anti‐viral treatment in Egypt 下载免费PDF全文